Application of mouse model for effective evaluation of foot-and-mouth disease vaccine

Lee, Seo-Yong; Ko, Mi-Kyeong; Lee, Kwang‐Nyeong; Choi, Joo-Hyung; You, Su-Hwa; Pyo, Hyun-Mi; Lee, Myoung-Heon; Kim, Byounghan; Lee, Jong-Soo

doi:10.1016/j.vaccine.2016.06.008

Cited by 11 publications

(7 citation statements)

References 23 publications

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“…The mouse model has been and continues to be used in numerous studies to evaluate the efficacy of new‐generation vaccines against FMD (Berinstein et al., 1993; Borca et al., 1984; García‐Nuñez, König, Berinstein, & Carrillo, 2010; Langellotti et al., 2012; Lee et al., 2016; Mignaqui et al., 2013; Molin‐Capeti et al, 2013; Quattrocchi et al., 2013; Rodriguez Pulido, Sobrino, Borrego, & Saiz, 2009; Romanutti et al., 2013; Shi, Wang, & Wang, 2007).…”

Section: Discussionmentioning

confidence: 99%

Mouse model as an efficacy test for foot‐and‐mouth disease vaccines

Gnazzo

Quattrocchi

Soria

et al. 2020

Transbound. Emerg. Dis.

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Foot-and-mouth disease virus (FMDV) is a picornavirus belonging to the Aphthovirus genus (Soria et al., 2017). FMDV has seven distinct serotypes, namely O, A, C, SAT1, SAT2, SAT3 and Asia 1. This virus produces foot-and-mouth disease (FMD), a devastating and highly transmissible infection of farm animals, with large associated economic losses. Some countries are either FMD free or close to achieving eradication, while others are at an early stage of FMD control. In many countries, FMD control is performed by regular vaccination based on inactivated whole virus (Soria et al., 2017).

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Section: Discussionmentioning

confidence: 99%

Mouse model as an efficacy test for foot‐and‐mouth disease vaccines

Gnazzo

Quattrocchi

Soria

et al. 2020

Transbound. Emerg. Dis.

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“…A superior animal model is needed to show the low cost, easy acquisition, easy operation advantages, and ability of simulating the pathogenesis of humans. Newborn mice have been used as a model of various enterovirus infections to preclinically evaluate vaccines (23)(24)(25)(26)(27)(28). With the increase in CVA6 infection rate over the past few years, CVA6 isolated clinically was used to build the corresponding infection models in newborn mice by intraperitoneal, intramuscular, and intradermic injection methods (17), as an attempt to develop vaccines and antiviral drugs for preventing and treating CVA6.…”

Section: Discussionmentioning

confidence: 99%

“…Likewise, the newborn mice at age 6-, 8-, 10-, 12-, and 14-day were inoculated. Their clinical symptoms were scored according to the clinical 5-grade scoring standard as previously reported in a report on CVA16 ( 23 ), i.e., 0, 1, 2, 3, and 4, respectively, represent healthy, lethargic or depressed, emaciated and slow-moving, hind limb paralyzed, and dead. Lastly, a CVA6 mouse-adapted strain capable of causing clinical symptoms above grade 3 in the 10-day-old mice was generated and termed as CVA6-A.…”

Section: Methodsmentioning

confidence: 99%

A 10-Day-Old Murine Model of Coxsackievirus A6 Infection for the Evaluation of Vaccines and Antiviral Drugs

Jiang¹,

Zhang

Lin³

et al. 2021

Front. Immunol.

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Coxsackievirus A6 (CVA6) is recognized as a major enterovirus type that can cause severe hand, foot, and mouth disease and spread widely among children. Vaccines and antiviral drugs may be developed more effectively based on a stable and easy-to-operate CVA6 mouse infection model. In this study, a wild CVA6-W strain was sub-cultured in newborn mice of different ages (in days), for adaptation. Therefore, a CVA6-A mouse-adapted strain capable of stably infecting the mice was generated, and a fatal model was built. As the result indicated, CVA6-A could infect the 10-day-old mice to generate higher levels of IFN-γ, IL-6, and IL-10. The mice infected with CVA6-A were treated with IFN-α1b at a higher dose, with complete protection. Based on this strain, an animal model with active immunization was built to evaluate antiviral protection by active immunization. The three-day-old mice were pre-immunized with inactivated CVA6 thereby generating IgM and IgG antibodies within 7 days that enabled complete protection of the pre-immunized mice following the CVA6 virus challenge. There were eight mutations in the genome of CVA6-A than in that of CVA6-W, possibly attributed to the virulence of CVA6 in mice. Briefly, the CVA6 infection model of the 10-day-old mice built herein, may serve as an applicable preclinical evaluation model for CVA6 antiviral drugs and vaccine study.

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“…Mice model is employed for measuring the immune responses induced by vaccines and the pathogenesis of virus challenge before testing them in host animals (Lee et al, 2016). There were different pathogenesis of virus infection with different animal strain and various vaccines.…”

Section: Discussionmentioning

confidence: 99%

“…The result showed that serotype O, A and Asia1 FMDVs that were non-pathogenic in C57BL/6 mice gained pathogenicity after the repeated passages in mice and cells. This study revealed that FMD vaccine evaluation should be carried out using mouseadapted challenge viruses as an effective test of experimental or commercial vaccines (Lee et al, 2016). Although the inactivated FMD vaccine has been successfully used for many years, animals must be revaccinated to maintain immune responses because of a decline in efficacy.…”

Section: Introductionmentioning

confidence: 99%

Vitamin C supplementation improved the efficacy of foot-and-mouth disease vaccine

Kang

2017

Food and Agricultural Immunology

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Vitamin C (VC) is an essential micronutrient and plays important roles in various biological processes including immune responses. Vaccination can stimulate immune responses effectively for prevention of virual infection. Adequate VC intake is required for the immune system to function efficiently. In this study, we evaluated the biological function of VC on immune response to inactivated foot-and-mouth disease (FMD) vaccine. The C57BL/6 mice were injected intraperitoneally with different dose of VC daily following immunization with inactivated FMD vaccine. The results showed high dose of VC supplementation significantly increased IgG level. Similarly, high dose of VC supplementation enhanced Th2 and Th17 cellular immune responses and also increased MHCII expression on dendritic cells. Taken together, these data indicate that high dose of VC supplementation can modulate Th2 and Th17 cellular immune responses to inactivated FMD vaccine and manifest the necessity for effective vaccination.

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Application of mouse model for effective evaluation of foot-and-mouth disease vaccine

Cited by 11 publications

References 23 publications

Mouse model as an efficacy test for foot‐and‐mouth disease vaccines

Mouse model as an efficacy test for foot‐and‐mouth disease vaccines

A 10-Day-Old Murine Model of Coxsackievirus A6 Infection for the Evaluation of Vaccines and Antiviral Drugs

Vitamin C supplementation improved the efficacy of foot-and-mouth disease vaccine

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