“…However, none of the treatments changed the expression of esr2a and nor were able to distress the sex ratio in tambaqui. Such data is contradictory to the masculinization effect of aromatase inhibitors widely reported in a variety of fish species (Babiak et al, 2012, Shen et al, 2015, Evliyaoglu et al, 2019, Qin et al, 2020, Ayobahan et al, 2020, even at very low concentrations (Muth-Köhne et al, 2016, Joshi et al, 2019. And also incompatible to the tamoxifen effect that, acting as either agonist or antagonist, stimulating or inhibiting gonadal differentiation, leads to abnormal sexual development and biased sex ratio (Singh et al, 2012, Navarro-Martín et al, 2009, Singh et al, 2015, García-Hernández et al, 2016, Pandit et al, 2017.…”