Application of Natural Deep Eutectic Solvents in Biomass Pretreatment, Enzymatic Saccharification and Cellulosic Ethanol Production

Kumar, Adepu K.; Parikh, Bhumika S.; Liu, Lewis Z.; Cotta, Michael A.

doi:10.1016/j.matpr.2018.11.035

Cited by 15 publications

(9 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NADES are solvents of great interest in chemistry, due to their unique solvent properties, including high extraction ability for some natural products and high solubilisation strength of a wide range of organic and inorganic compounds [ 35 , 42 , 43 , 44 ]. NADES are simply prepared, cost effective, eco-friendly green solvents outcompeting existing organic solvents [ 45 ], in addition to being renewable and biodegradable [ 43 ] and easily tunable [ 46 ]. NADES applications have been reported for extraction of phenolic compounds for cosmetic, pharmaceutical and food industries [ 47 , 48 , 49 , 50 ], but they are also evaluated in a broad range of fields including analytical chemistry [ 35 ], organic synthesis [ 51 ], biotechnologies [ 52 ], electrochemistry [ 53 ], or nanotechnology [ 54 , 55 , 56 ].…”

Section: Introductionmentioning

confidence: 99%

In Situ Water Quantification in Natural Deep Eutectic Solvents Using Portable Raman Spectroscopy

et al. 2021

View full text Add to dashboard Cite

Raman spectroscopy is a label-free, non-destructive, non-invasive analytical tool that provides insight into the molecular composition of samples with minimum or no sample preparation. The increased availability of commercial portable Raman devices presents a potentially easy and convenient analytical solution for day-to-day analysis in laboratories and production lines. However, their performance for highly specific and sensitive analysis applications has not been extensively evaluated. This study performs a direct comparison of such a commercially available, portable Raman system, with a research grade Raman microscope system for the analysis of water content of Natural Deep Eutectic Solvents (NADES). NADES are renewable, biodegradable and easily tunable “green” solvents, outcompeting existing organic solvents for applications in extraction from biomass, biocatalysis, and nanoparticle synthesis. Water content in NADES is, however, a critical parameter, affecting their properties, optimal use and extraction efficiency. In the present study, portable Raman spectroscopy coupled with Partial Least Squares Regression (PLSR) is investigated for rapid determination of water content in NADES samples in situ, i.e., directly in glassware. Three NADES systems, namely Betaine Glycerol (BG), Choline Chloride Glycerol (CCG) and Glucose Glycerol (GG), containing a range of water concentrations between 0% (w/w) and 28.5% (w/w), were studied. The results are directly compared with previously published studies of the same systems, using a research grade Raman microscope. PLSR results demonstrate the reliability of the analysis, surrendering R2 values above 0.99. Root Mean Square Errors Prediction (RMSEP) of 0.6805%, 0.9859% and 1.2907% w/w were found for respectively unknown CCG, BG and GG samples using the portable device compared to 0.4715%, 0.3437% and 0.7409% w/w previously obtained by analysis in quartz cuvettes with a Raman confocal microscope. Despite the relatively higher values of RMSEP observed, the comparison of the percentage of relative errors in the predicted concentration highlights that, overall, the portable device delivers accuracy below 5%. Ultimately, it has been demonstrated that portable Raman spectroscopy enables accurate quantification of water in NADES directly through glass vials without the requirement for sample withdrawal. Such compact instruments provide solvent and consumable free analysis for rapid analysis directly in laboratories and for non-expert users. Portable Raman is a promising approach for high throughput monitoring of water content in NADES that can support the development of new analytical protocols in the field of green chemistry in research and development laboratories but also in the industry as a routine quality control tool.

show abstract

Section: Introductionmentioning

confidence: 99%

In Situ Water Quantification in Natural Deep Eutectic Solvents Using Portable Raman Spectroscopy

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The synergic effects of alternative solvents and US energy have shown a promising eco-friendly process for biomass valorization [137] . Some successful examples can be highlighted, as the production of furanic platforms in ionic liquids/US horn [80] , the extraction of bioactive compounds from grape pomace in natural deep eutectic solvents/US horn [99] , and the lignin removal from wheat straw in deep eutectic solvents/US bath [139] , [140] .…”

Section: Developments Based On the Use Of Alternative “Green” Solventmentioning

confidence: 99%

Ultrasound-assisted biomass valorization to industrial interesting products: state-of-the-art, perspectives and challenges

Flores

Cravotto

Bizzi

et al. 2021

Ultrasonics Sonochemistry

View full text Add to dashboard Cite

“…NADES have unique solvent properties, such as high extraction ability and high solubilisation strength for a wide range of organic and inorganic compounds [ 2 , 4 , 5 , 6 ]. In addition to being easily prepared, cost effective and easily tuneable for specific applications, they can outcompete other solvents in terms of extraction rates and efficacy [ 6 , 7 , 8 ]. NADES are increasingly studied for numerous reported applications including analytical chemistry [ 4 ], organic synthesis [ 9 ], biotechnology [ 10 , 11 ], electrochemistry [ 12 ], nanotechnology [ 13 , 14 , 15 ], energy [ 16 ], water remediation [ 17 ], cosmetics and pharmaceutics [ 18 , 19 ] and food industries [ 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Vibrational Spectroscopic Techniques for Quantification of Water in Natural Deep Eutectic Solvents

et al. 2022

View full text Add to dashboard Cite

Vibrational spectroscopic techniques, i.e., attenuated total reflectance infrared (ATR-IR), near infrared spectroscopy (NIRS) and Raman spectroscopy (RS), coupled with Partial Least Squares Regression (PLSR), were evaluated as cost-effective label-free and reagent-free tools to monitor water content in Levulinic Acid/L-Proline (LALP) (2:1, mol/mol) Natural Deep Eutectic Solvent (NADES). ATR-IR delivered the best outcome of Root Mean Squared Error (RMSE) of Cross-Validation (CV) = 0.27% added water concentration, RMSE of Prediction (P) = 0.27% added water concentration and mean % relative error = 2.59%. Two NIRS instruments (benchtop and handheld) were also compared during the study, respectively yielding RMSECV = 0.35% added water concentration, RMSEP = 0.56% added water concentration and mean % relative error = 5.13% added water concentration, and RMECV = 0.36% added water concentration, RMSEP = 0.68% added water concentration and mean % relative error = 6.23%. RS analysis performed in quartz cuvettes enabled accurate water quantification with RMECV = 0.43% added water concentration, RMSEP = 0.67% added water concentration and mean % relative error = 6.75%. While the vibrational spectroscopic techniques studied have shown high performance in relation to reliable determination of water concentration, their accuracy is most likely related to their sensitivity to detect the LALP compounds in the NADES. For instance, whereas ATR-IR spectra display strong features from water, Levulinic Acid and L-Proline that contribute to the PLSR predictive models constructed, NIRS and RS spectra are respectively dominated by either water or LALP compounds, representing partial molecular information and moderate accuracy compared to ATR-IR. However, while ATR-IR instruments are common in chemistry and physics laboratories, making the technique readily transferable to water quantification in NADES, Raman spectroscopy offers promising potential for future development for in situ, sample withdrawal-free analysis for high throughput and online monitoring.

show abstract

Application of Natural Deep Eutectic Solvents in Biomass Pretreatment, Enzymatic Saccharification and Cellulosic Ethanol Production

Cited by 15 publications

References 13 publications

In Situ Water Quantification in Natural Deep Eutectic Solvents Using Portable Raman Spectroscopy

In Situ Water Quantification in Natural Deep Eutectic Solvents Using Portable Raman Spectroscopy

Ultrasound-assisted biomass valorization to industrial interesting products: state-of-the-art, perspectives and challenges

Comparison of Vibrational Spectroscopic Techniques for Quantification of Water in Natural Deep Eutectic Solvents

Contact Info

Product

Resources

About