Application of natural deep eutectic solvents to the extraction of anthocyanins from Catharanthus roseus with high extractability and stability replacing conventional organic solvents

Enhanced extraction of phenolic compounds using choline chloride based deep eutectic solvents from Juglans regia L.

“…Then, the HBA and HBD can be selected to be less toxic than organic volatile solvents and also biodegradable (Mbous et al, 2017). Moreover, in general, these solvents have low volatility and flammability (Dai et al, 2016). The addition of water to DES, for extraction purposes, is a wellestablished procedure to reduce the viscosity of the solvents and improve the mass transfer of bioactive molecules from the natural matrices (García et al, 2016;Gu et al, 2014).…”

“…The addition of water to DES, for extraction purposes, is a wellestablished procedure to reduce the viscosity of the solvents and improve the mass transfer of bioactive molecules from the natural matrices (García et al, 2016;Gu et al, 2014). Regarding temperature, its increase leads to a lower viscosity and, consequently, to higher extraction yields (Dai et al, 2016;Jancheva et al, 2017).…”

“…First, they are simple to prepare from cheap starting materials (Dai et al, 2016). Then, the HBA and HBD can be selected to be less toxic than organic volatile solvents and also biodegradable (Mbous et al, 2017).…”

“…Choi et al (2011) introduced the DES as an alternative media to extract secondary metabolites, such as phenolic compounds, from natural matrices instead of conventional organic solvents. Nowadays, this idea is being expanded to create designer solvents, using several combinations of HBA and HBD, with tunable properties to selectively dissolve and extract natural and bioactive compounds from plants, oils or biomass, valorizing natural products or wastes as a source of valuable compounds (Dai et al, 2016;Nam et al, 2015;Paradiso et al, 2016). A very recent review on the application of deep eutectic solvents for the extraction of phenolic compounds can be found in literature, describing the possibility of using DES both as solvent and formulation media with potential cosmetics, pharmaceutical, or food applications (Ruesgas-Ramón et al, 2017).…”

Development of a Method Based on Natural Deep Eutectic Solvents for Extraction of Flavonoids from Food Samples

“…NADES therefore have good potential for the extraction of valuable secondary metabolites for use in the food and pharmaceutical industries. Recently, NADES have been applied for extraction of flavonoids (Wei et al 2015a;Radošević et al 2016;Bakirtzi et al 2016;Dai et al 2016), alkaloids, phenolic acids, anthraquinones, saponins (Duan et al 2016, phenolic compounds (Wei et al 2015b), xanthonoids (Mulia et al 2015), rutin (Huang et al 2017), flavonoid glycosides, and aglycones (Zhuang et al 2017) from plant materials. The mentioned publications describe the extraction of flavonoids other than those described in our research and the application of different NADES solvents for sample preparation.…”