Application of Near-Infrared Dyes for Tumor Imaging, Photothermal, and Photodynamic Therapies

Yuan, Ahu; Wu, Jinhui; Tang, Xiaolei; Zhao, Lili; Xu, Feng; Hu, Yiqiao

doi:10.1002/jps.23356

Cited by 251 publications

(170 citation statements)

References 120 publications

(143 reference statements)

Supporting

Mentioning

165

Contrasting

Unclassified

Order By: Relevance

“…As a result, laser radiation with fiber-optic waveguides, which is called laser hyperthermia, finds growing applications in cancer therapy. In this procedure, a biocompatible photothermal therapy agent with a large absorption coefficient in the near infrared regions and a near infrared light source [164]. Thus, surface-modified nanomaterials of carbon, metals, and semiconductors with near infrared absorption can be ideal photothermal therapy agents.…”

Section: Photothermal Therapymentioning

confidence: 99%

A biotechnological perspective on the application of iron oxide nanoparticles

et al. 2016

View full text Add to dashboard Cite

In recent decades, magnetic iron nanoparticles (NPs) have attracted much attention due to properties such as superparamagnetism, high surface area, large surface-to-volume ratio, and easy separation under external magnetic fields. Therefore, magnetic iron oxides have potential for use in numerous applications, including magnetic resonance imaging contrast enhancement, tissue repair, immunoassay, detoxification of biological fluids, drug delivery, hyperthermia, and cell separation. This review provides an updated and integrated focus on the fabrication and characterization of suitable magnetic iron NPs for biotechnological applications. The possible perspective and some challenges in the further development of these NPs are also discussed.

show abstract

Section: Photothermal Therapymentioning

confidence: 99%

A biotechnological perspective on the application of iron oxide nanoparticles

et al. 2016

View full text Add to dashboard Cite

show abstract

“…When excited by light at a certain wavelength, photosensitizers facilitate the generation of cytotoxic free radicals (Figure 4). 3 These products affect tumor growth by destroying the abnormal neovasculature directly. They also initiate an inflammatory microenvironment that leads to cancer cell death.…”

Section: Photodynamic Therapymentioning

confidence: 99%

Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field

Yi¹,

Wang²,

Qin³

et al. 2014

IJN

213

149

View full text Add to dashboard Cite

Near-infrared fluorescence (NIRF) imaging is an attractive modality for early cancer detection with high sensitivity and multi-detection capability. Due to convenient modification by conjugating with moieties of interests, NIRF probes are ideal candidates for cancer targeted imaging. Additionally, the combinatory application of NIRF imaging and other imaging modalities that can delineate anatomical structures extends fluorometric determination of biomedical information. Moreover, nanoparticles loaded with NIRF dyes and anticancer agents contribute to the synergistic management of cancer, which integrates the advantage of imaging and therapeutic functions to achieve the ultimate goal of simultaneous diagnosis and treatment. Appropriate probe design with targeting moieties can retain the original properties of NIRF and pharmacokinetics. In recent years, great efforts have been made to develop new NIRF probes with better photostability and strong fluorescence emission, leading to the discovery of numerous novel NIRF probes with fine photophysical properties. Some of these probes exhibit tumoricidal activities upon light radiation, which holds great promise in photothermal therapy, photodynamic therapy, and photoimmunotherapy. This review aims to provide a timely and concise update on emerging NIRF dyes and multifunctional agents. Their potential uses as agents for cancer specific imaging, lymph node mapping, and therapeutics are included. Recent advances of NIRF dyes in clinical use are also summarized.

show abstract

“…As a non-toxic organic near-infrared (NIR) dye ICG is also an attractive photosensitizer for PDT due to its strong absorption at 805 nm with minimal bioscattering and limited autofluorescence of biomolecules at this wavelength. Consequently, deeper tissue penetration and higher signal-to-noise ratio images can be achieved using ICG as opposed to other photosensitizers excited at shorter wavelengths (17,18).…”

Section: Introductionmentioning

confidence: 99%