Application of optical coherence tomography in non‐invasive characterization of skin vascular lesions

Salvini, Camilla; Massi, Daniela; Cappetti, Alessio; Stante, Marcello; Cappugi, Pietro; Fabbri, Paolo; Carli, Paolo

doi:10.1111/j.1600-0846.2007.00265.x

Cited by 24 publications

(28 citation statements)

References 13 publications

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“…These details may have some applicability in laser treatment of haemangiomas, and future studies to explore OCT imaging of haemangiomas are necessary. Previous studies demonstrated a 3D OCT image of a similar lesion [57] and in another study OCT images matched histology of haemangiomas [58]. The use of Doppler OCT may have a potential for identifying feeding vessels and prognosis estimation in capillary haemangiomas and vessels in general during laser treatment, which has been demonstrated using Doppler US [59], and in a study of one port-wine stain by Doppler OCT [60].…”

Section: Haemangiomasmentioning

confidence: 75%

OCT imaging of skin cancer and other dermatological diseases

Mogensen

Thrane

Jørgensen

et al. 2009

Journal of Biophotonics

175

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Optical coherence tomography (OCT) provides clinicians and researchers with micrometer-resolution, in vivo, cross-sectional images of human skin up to several millimeter depth. This review of OCT imaging applied within dermatology covers the application of OCT to normal skin, and reports on a large number of applications in the fields of non-melanoma skin cancer, malignant melanomas, psoriasis and dermatitis, infestations, bullous skin diseases, tattoos, nails, haemangiomas, and other skin diseases.

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Section: Haemangiomasmentioning

confidence: 75%

OCT imaging of skin cancer and other dermatological diseases

Mogensen

Thrane

Jørgensen

et al. 2009

Journal of Biophotonics

175

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“…OCT provided optical biopsies based on the detection of inhomogeneities such as roundish-shaped or oval signal-poor cavities. The signal-poor regions indicating vascular structures sharply demarcate from the signal-rich microenvironment [11]. The pre-therapeutic knowledge of the lumen and the depth of the vessels can optimize the treatment of hemangiomas and vascular malfunctions.…”

Section: Resultsmentioning

confidence: 99%

“…OCT systems have been used in dermatology since the 90s mainly for experimental and clinical studies. The morphology and epidermal thickness of normal skin has been investigated [8] as well as bullous diseases [8], psoriasis, contact dermatitis [9], melanocytic lesions [10], and vascular lesions [11]. In contrast to ophthalmology, the technique is not yet applicable for routine diagnostics in dermatology and is still under development.…”

Section: Biophotonicsmentioning

confidence: 99%

Clinical optical coherence tomography combined with multiphoton tomography of patients with skin diseases

König

Speicher²,

Bückle

et al. 2009

Journal of Biophotonics

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We report on the first clinical study based on optical coherence tomography (OCT) in combination with multiphoton tomography (MPT) and dermoscopy. 47 patients with a variety of skin diseases and disorders such as skin cancer, psoriasis, hemangioma, connective tissue diseases, pigmented lesions, and autoimmune bullous skin diseases have been investigated with (i) state-of-the-art OCT systems for dermatology including multibeam swept source OCT, (ii) the femtosecond laser multiphoton tomograph, and (iii) dermoscopes. Dermoscopy provides two-dimensional color images of the skin surface. OCT images reflect modifications of the intratissue refractive index whereas MPT is based on nonlinear excitation of endogenous fluorophores and second harmonic generation. A stack of cross-sectional OCT "wide field" images with a typical field of view of 5 x 2 mm(2) gave fast information on the depth and the volume of the lesion. Multiphoton tomography provided 0.36 x 0.36 mm(2) horizontal/diagonal optical sections within seconds of a particular region of interest with superior submicron resolution down to a tissue depth of 200 mum. The combination of OCT and MPT provides a unique powerful optical imaging modality for early detection of skin cancer and other skin diseases as well as for the evaluation of the efficiency of treatments.

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“…However, in the present study, it was not possible to find significant differences between the formulations and control. As non-invasive equipment, Cutometer ® has made it possible to study the mechanical properties of skin and evaluate the effect of cream when used in certain conditions (28). Although the results were not considered statistically significant, they indicate that the effects of chamomile extract after single or 2-and 4-weeks of daily applications were more pronounced on hydration properties of skin.…”

Section: Discussionmentioning

confidence: 99%

“…No entanto, no presente estudo, não foi possível determinar diferenças significativas entre as formulações e o controlo. Como equipamento não-invasivo, o Cutometer ® tornou possível estudar as propriedades mecânicas da pele e avaliar o efeito do creme nas condições de utilização (28). Embora os resultados obtidos não tenham sido considerados estatisticamente significativos, estes indicam que os efeitos do extracto de camomila, após única aplicação ou 2 -e 4 semanas de aplicação diária foram mais pronunciados nas propriedades de hidratação da pele, o que pode implicar que seja possível encontrar efeitos significativos sobre as propriedades mecânicas da pele, se os tratamentos forem aplicados por um período de tempo mais longo.…”

Section: Discussionunclassified

Antioxidant activity of Matricaria chamomilla L. extract and clinical efficacy of cosmetic formulations containing this extract and its isolated compounds

Nóbrega

Wagemaker

Campos

2013

BBR

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249 Biomedical and Biopharmaceutical Research J o r n a l d e I n v e s t i g a ç ã o B i o m é d i c a e B i o f a r m a c ê u t i c a Antioxidant activity of Matricaria chamomilla L. extract and clinical efficacy of cosmetic formulations containing this extract and its isolated compounds AbstractTopical application of antioxidants has proven to be effective in protecting the skin against oxidative damage. Matricaria chamomilla L. extract has been used in cosmetic formulations. The aim of this study was to evaluate the antioxidant potential of chamomile extract as well as the clinical efficacy on skin hydration and mechanical properties of skin. The antioxidant activity of chamomile extract was evaluated by chemiluminescence (IC50 = 0.14 μg/mL). Stable formulations were supplemented with 0,5 cg/g α-bisabolol or cg/gwith 5,0 of Matricaria chamomile glycolic extract or with 0,01 cg/g of apigenin and applied on the volar forearm and face of 25 female subjects. Skin physiology was assessed before and after 2 hours (single application) and after a 2-and 4-week period of daily application. After a single application, all formulations increased the stratum corneum water content but only α-bisabolol and chamomile extract formulations reduced TEWL. The formulation with chamomile extract has shown the most pronounced result in the reduction of TEWL (27%). However, after 2-and 4-week application, only the extract formulation increased stratum corneum water content compared with the vehicle. Chamomile extract was effective in neutralizing free radicals and therefore presents an interesting potential in cosmetic formulations for this purpose. Keywords:Chamomile, Clinical Efficacy, Antioxidant Activity, Apigenin, Alpha-Bisabolol, ResumoA aplicação tópica de antioxidantes provou ser eficaz em proteger a pele contra danos oxidativos. O extracto de Matricaria chamomilla L. tem sido amplamente utilizado em formulações cosméticas. Assim, o objectivo deste estudo foi avaliar o potencial antioxidante do extracto de camomila, bem como a eficácia clínica na hidratação e nas propriedades mecânicas da pele. A actividade antioxidante do extracto de camomila foi avaliada por quimioluminescência (IC50 = 0,14 ug / mL). As formulações foram suplementadas com a α -bisabolol de fração mássica 0,5 cg/g ou com extracto glicólico de Matricaria chamomilla L. de fração mássica 5,0 cg/g ou com 0,01 cg/g de apigenina e aplicados na parte interna do antebraço e na cara de 25 mulheres. A fisiologia da pele foi avaliada antes e após 2 horas (aplicação única) e 2 e 4 semanas de aplicação diária. Depois de uma única aplicação, todas as formulações aumentaram a água do estrato córneo, mas apenas as formulações com α -bisabolol e extracto de camomila reduziram a PTEA . A formulação com o extracto de camomila mostrou o resultado mais marcante na redução PTEA (27%). No entanto, após 2 -e 4-semanas de aplicação, apenas a formulação contendo o extracto aumentou o a água no estrato córneo. O extracto de camomila, foi eficaz na neutralização de radicais livres e...

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Application of optical coherence tomography in non‐invasive characterization of skin vascular lesions

Abstract: The analysis of vascular lesions by OCT provides a new insight into non-invasive diagnosis and can be helpful in the selection of the most appropriate treatment.

Cited by 24 publications

References 13 publications

OCT imaging of skin cancer and other dermatological diseases

OCT imaging of skin cancer and other dermatological diseases

Clinical optical coherence tomography combined with multiphoton tomography of patients with skin diseases

Antioxidant activity of Matricaria chamomilla L. extract and clinical efficacy of cosmetic formulations containing this extract and its isolated compounds

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