Application of Optogenetics for Muscle Cells and Stem Cells

Asano, Takao; Teh, Daniel Boon Loong; Yawo, Hiromu

doi:10.1007/978-981-15-8763-4_23

Cited by 6 publications

(5 citation statements)

References 68 publications

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“…Initially, optogenetic research focused primarily on brain or spinal cord neurons. However, the scope of research has gradually expanded to include the peripheral nervous system and non-neuronal systems, such as skeletal, smooth or cardiac muscles, glial, stem cells, endocrine cells, et al ( Jia et al, 2011 ; Bruegmann et al, 2015 ; Park et al, 2017 ; Xie et al, 2020 ; Asano et al, 2021 ; Yang et al, 2022 ). Optogenetics has also led to many new discoveries about the neural circuitry underlying disease-related symptoms.…”

Section: Discussionmentioning

confidence: 99%

A bibliometric profile of optogenetics: quantitative and qualitative analyses

Zhou

Wang

et al. 2023

Front. Neurosci.

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IntroductionOptogenetics is a rapidly developing field combining optics and genetics, with promising applications in neuroscience and beyond. However, there is currently a lack of bibliometric analyses examining publications in this area.MethodPublications on optogenetics were gathered from the Web of Science Core Collection Database. A quantitative analysis was conducted to gain insights into the annual scientific output, and distribution of authors, journals, subject categories, countries, and institutions. Additionally, qualitative analysis, such as co-occurrence network analysis, thematic analysis, and theme evolution, were performed to identify the main areas and trends of optogenetics articles.ResultsA total of 6,824 publications were included for analysis. The number of articles has rapidly grown since 2010, with an annual growth rate of 52.82%. Deisseroth K, Boyden ES, and Hegemann P were the most prolific contributors to the field. The United States contributed the most articles (3,051 articles), followed by China (623 articles). A majority of optogenetics-related articles are published in high-quality journals, including NATURE, SCIENCE, and CELL. These articles mainly belong to four subjects: neurosciences, biochemistry and molecular biology, neuroimaging, and materials science. Co-occurrence keyword network analysis identified three clusters: optogenetic components and techniques, optogenetics and neural circuitry, optogenetics and disease.ConclusionThe results suggest that optogenetics research is flourishing, focusing on optogenetic techniques and their applications in neural circuitry exploration and disease intervention. Optogenetics is expected to remain a hot topic in various fields in the future.

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Section: Discussionmentioning

confidence: 99%

A bibliometric profile of optogenetics: quantitative and qualitative analyses

Zhou

Wang

et al. 2023

Front. Neurosci.

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“…Recent advances in the field of optogenetics have provided a unique opportunity to visualize or modify the activity of distinct populations of cells within intact preparations using light stimulation and genetic manipulation (Asano et al., 2021). Optogenetic techniques can be split into activators/inactivators (such as light activated rhodopsins) and reporters (such as genetically encoded Ca 2+ indicators (GECIs)).…”

Section: The Sip (Smooth Muscle Cells Interstitial Cells Of Cajal And...mentioning

confidence: 99%

Insights on gastrointestinal motility through the use of optogenetic sensors and actuators

Drumm

Cobine

Baker

2022

The Journal of Physiology

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“…Targeting neurogenesis with drugs and compounds affecting some of the above-mentioned regulatory mechanisms is in the focus of neurobiologists and neuropharmacologists. At the same time, given the rapid development of optogenetics, it is not surprising that this method has already been repeatedly tested to modulate the adult neurogenesis with higher precision either in vivo or in vitro [128,129]. Indeed, neural stem or progenitor cells could be transfected with light-sensitive channelrhodopsin2 (ChR2) or other variants of chimeric opsins, for the induction of large photocurrents, either with viral vectors (i.e., lentivirus) or via a non-viral transfection system (i.e., piggy-Bac transposons).…”

Section: Adult Neurogenesis As a Target For Therapy And Optogenetic Controlmentioning

confidence: 99%

Novel Approaches Used to Examine and Control Neurogenesis in Parkinson′s Disease

Салмина

Kapkaeva

Ветчинова

et al. 2021

IJMS

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Neurogenesis is a key mechanism of brain development and plasticity, which is impaired in chronic neurodegeneration, including Parkinson’s disease. The accumulation of aberrant α-synuclein is one of the features of PD. Being secreted, this protein produces a prominent neurotoxic effect, alters synaptic plasticity, deregulates intercellular communication, and supports the development of neuroinflammation, thereby providing propagation of pathological events leading to the establishment of a PD-specific phenotype. Multidirectional and ambiguous effects of α-synuclein on adult neurogenesis suggest that impaired neurogenesis should be considered as a target for the prevention of cell loss and restoration of neurological functions. Thus, stimulation of endogenous neurogenesis or cell-replacement therapy with stem cell-derived differentiated neurons raises new hopes for the development of effective and safe technologies for treating PD neurodegeneration. Given the rapid development of optogenetics, it is not surprising that this method has already been repeatedly tested in manipulating neurogenesis in vivo and in vitro via targeting stem or progenitor cells. However, niche astrocytes could also serve as promising candidates for controlling neuronal differentiation and improving the functional integration of newly formed neurons within the brain tissue. In this review, we mainly focus on current approaches to assess neurogenesis and prospects in the application of optogenetic protocols to restore the neurogenesis in Parkinson’s disease.

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Application of Optogenetics for Muscle Cells and Stem Cells

Cited by 6 publications

References 68 publications

A bibliometric profile of optogenetics: quantitative and qualitative analyses

A bibliometric profile of optogenetics: quantitative and qualitative analyses

Insights on gastrointestinal motility through the use of optogenetic sensors and actuators

Novel Approaches Used to Examine and Control Neurogenesis in Parkinson′s Disease

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