Application of Oral Absorption in Establishment of AOEL for Pesticides and Occupational Risk Assessment for farm worker

You, Are-Sun; Hong, Sung-Chang; Lee, Je Bong; Lee, Seungdon; Ihm, Yang-Bin

doi:10.7585/kjps.2014.18.4.342

Cited by 4 publications

(3 citation statements)

References 5 publications

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“…In many cases, AOEL was set based on NOAEL of 90 days or short-term toxicity and by considering uncertainties of interspecies and individual differences and data gaps of studies (Damalas and Eleftherohorinos, 2011;Hong et al, 2007Hong et al, , 2010You et al, 2014). In addition, the oral absorption rate was used as a correction factor to convert the external dose to the internal dose when oral absorption rate was less than 80% (You et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

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Comparative Estimation of Exposure Level and Health Risk Assessment of Highly Produced Pesticides to Agriculture Operators by Using Default Dermal Absorption Rate or Actual Measurement Values

Kim

Lee

Kim

et al. 2016

BSL

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Pesticides are widely used to prevent loss of agricultural production but extensive exposure can induce health problems to pesticide operators. This study was performed to evaluate the health risk of highly produced pesticides used in fruit growing farm land by comparison of estimated exposure level with AOEL using KO-POEM program. AOEL was driven based on NOAEL of each pesticide evaluated by JMPR, EFSA or KRDA. In calculation of exposure level, types of formulation, dilution factors, spraying duration and motor type and exposure protection device were allocated according to actual condition of use. Dermal absorption rate was differently applied among EFSA default values (25% or 75%), general default value (10%) or real test result values to know the plausibility of default values and safety of pesticide to operators in outline. Twenty pesticide ingredients (fungicides and insecticides) were produced more than 30 tons per year, which were mancozeb, chlorothalonil, imidaclopirid and etc in order. Dermal absorption rates obtained from studies were various from 0.07 to 81% but mostly under 10%. The estimated exposure levels showed big differences more than 10 times higher when using EFSA default rate and up to 5 times higher when using general rate of 10% comparing using rates of test results. Mancozeb, chlorthalonil, diazinon and chlorpyrifos presented still higher exposure level than AOEL even when using test absorption rate from study, which suggests that re-evaluation of AOEL or dermal exposure absorption rate or strict management are required for health protection of operators who use those four pesticides in farm land.

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Section: Discussionmentioning

confidence: 99%

“…to pesticide operators (Choi and Kim, 2014). Therefore, Acceptable Operator Exposure Level (AOEL) is established during authorization of pesticides to prevent the exposure level does not exceed operators' health protection level, AOEL (You et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Comparative Estimation of Exposure Level and Health Risk Assessment of Highly Produced Pesticides to Agriculture Operators by Using Default Dermal Absorption Rate or Actual Measurement Values

Kim

Lee

Kim

et al. 2016

BSL

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“…(acceptable operator exposure level, AOEL)을 설정한 후 농 작업자의 농약 노출시험 결과와 비교하여 농약 등록의 적합 성을 검토함으로써 농작업자의 농약 사용에 따른 위해 평가 를 수행하고 있다 (You et al, 2014). 농작업자의 노출평가는 직접측정법과 간접측정법으로 나 눌 수 있는데 각각 수동적 평가기법과 생물학적 평가기법으 로 표현하기도 한다 (Kim et al, 2011).…”

Section: 이재윤·노현호·박효경·정혜림·진미지·박경훈·김정한·경기성 정 제제를 하고 있다 농작업자에 대한 노출 평가의unclassified

Exposure Assessment of Apple Orchard Workers to the Insecticide Imidacloprid Using Whole Body Dosimetry During Mixing/Loading and Application

Lee¹,

Noh²,

Park³

et al. 2016

KJPS

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To evaluate exposure characteristics of the insecticide imidacloprid to apple orchard workers during treatment on orchard fields and evaluate its potential risk using a whole body dosimetry (WBD) method, 1,000-time diluted acephate+imidacloprid 25(20+5)% solutions were sprayed on 10 apple orchard fields in Cheongju with a speed sprayer at a rate of 3,000 L/ha/person, after put on clothes such as inner/ outer clothes, personal air pump with a IOM sampler, nitrile glove and mask. Exposure test included mixing, loading and application steps. The test pesticide imidacloprid residues in the collected samples were analyzed with a HPLC-DAD. Recoveries ranged from 81.5 to 108.6% for analytical method validation and from 73.8 to 86.7% for field recovery. Total exposed amounts to mixer/loader and applicator were found to be 0.0014-0.0279% of total applied active ingredient of imidacloprid. Glove exposure of both mixer/loader and applicator was higher than the other parts. Margins of safety of mixer/loader and applicator were calculated to be 97-355 and 46-196, respectively, indicating that exposure risk of imidacloprid to apple orchard workers by spraying with a speed sprayer was very low.

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Scrutinizing the interaction between metribuzin with glutathione reductase 2 from Arabidopsis thaliana: insight into the molecular toxicity in agriculture

Xiang

Zhu

Yang

et al. 2022

Environ Sci Pollut Res

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Application of Oral Absorption in Establishment of AOEL for Pesticides and Occupational Risk Assessment for farm worker

Cited by 4 publications

References 5 publications

Comparative Estimation of Exposure Level and Health Risk Assessment of Highly Produced Pesticides to Agriculture Operators by Using Default Dermal Absorption Rate or Actual Measurement Values

Comparative Estimation of Exposure Level and Health Risk Assessment of Highly Produced Pesticides to Agriculture Operators by Using Default Dermal Absorption Rate or Actual Measurement Values

Exposure Assessment of Apple Orchard Workers to the Insecticide Imidacloprid Using Whole Body Dosimetry During Mixing/Loading and Application

Scrutinizing the interaction between metribuzin with glutathione reductase 2 from Arabidopsis thaliana: insight into the molecular toxicity in agriculture

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