Application of Privileged Molecular Framework of 7‐Fluoro‐1,4‐benzodiazepin‐2‐one‐5‐methylcarboxylate to the Synthesis of Its 1‐ and 5‐Disubstituted Analogs of Medicinal Interest

Abstract

Synthetic potential of the privileged molecular framework of 7‐fluoro‐1,4‐benzodiazepin‐2‐one containing a methyl carboxylate substituent at its 5‐position was exploited to develop efficient protocols to the synthesis of several novel 5‐(1′,3′,4′)oxadiazole ring incorporated analogs of medicinal interest, appended with the Mannich's base motifs at the nitrogen atom in its seven‐membered ring.

Design, Synthesis, and Characterization of 1, 3‐disubstituted‐1,4‐benzodiazepine Derivatives

“…Derivatives of benzodiazepines are widely used as anticonvulsant, antianxiety, analgesic, sedative, anti‐depressive, and hypnotic agents as well as anti‐inflammatory agents . In the last decade, the area of biological interest of 1,5 and 1,4‐benzodiazepines has been extended to several diseases such as cancer, viral infection, and cardiovascular disorders . In addition,1,4‐benzodiazepines are key intermediates for the synthesis of various fused ring systems such astriazolo‐, oxadiazolo‐, oxazino‐ or furanobenzodiazepines .…”