Application of response surface methodology to optimise ultrasonic‐assisted extraction of four chromones in Radix Saposhnikoviae

Li, Wei; Wang, Zi; Sun, Yinshi; Chen, Li; Han, Li; Zheng, Yi-Nan

doi:10.1002/pca.1282

Cited by 53 publications

(34 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regression equation was graphically represented by the 3D response surface and 2D contour plots (15). From the 3D response surface curves and contour plots shown in Fig.…”

Section: Optimiszation Of Response Surface Methodology (Rsm)mentioning

confidence: 99%

“…To dried powder (5.0 g), the solvent was added (ethanol of 40, 60 or 80 %) in a defined liquid-solid ratio (20:1, 30:1, 40:1) and extracted with in ultrasonic bath for defined time intervals (15,30 and 45 min) at 50 kHz. The filtrate was collected and the residue was extracted two times according to the protocol given above.…”

Section: Extraction Of Coreopsis Tinctoria Flowering Topsmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of the Antioxidant Activity of Coreopsis Tinctoria Nuff. and Optimisation of Isolation by Response Surface Methodology

Lan

Lin

2014

Acta Pharmaceutica

View full text Add to dashboard Cite

Evaluation of the antioxidant activity of Coreopsis tinctoria Nuff. and optimisation of isolation by response surface methodologyThe aim of the present study was to determine the antioxidant activity of Coreopsis tinctoria flowering tops (CTFT). Studies were conducted to obtain suitable extraction conditions for chlorogenic acid, quercetin, luteolin, apigenin and kaempferol, which were identified and quantified by HPLC. Response surface methodology was employed to optimise the ultrasound-assisted extraction conditions including extraction time, ethanol concentration and liquid-solid ratio. The antioxidant activity of the extracts was analysed using various antioxidant models, such as DPPH, ABTS and hydroxyl radical scavenging assay. CTFT extracted for 15.0 min with ethanol at a concentration of 60.4 % and with liquidsolid ratio 27.5:1 possessed a considerable amounts of total flavonoids and polyphenols (18.9 %). This extract showed higher scavenging activity of ABTS and hydroxyl radical activity than rutin, however not in the DPPH test. We may assume that CTFT possess antioxidant and free radical scavenging potentials.

show abstract

“…Regression equation was graphically represented by the 3D response surface and 2D contour plots (15). From the 3D response surface curves and contour plots shown in Fig.…”

Section: Optimiszation Of Response Surface Methodology (Rsm)mentioning

confidence: 99%

Section: Extraction Of Coreopsis Tinctoria Flowering Topsmentioning

confidence: 99%

Evaluation of the Antioxidant Activity of Coreopsis Tinctoria Nuff. and Optimisation of Isolation by Response Surface Methodology

Lan

Lin

2014

Acta Pharmaceutica

View full text Add to dashboard Cite

show abstract

“…However, upon increasing the methanol concentration beyond 65%, there was a gradual decline in the response, and extraction times over 30 min did not show any obvious effect on extraction yield. The results may be explained by the fact that increasing extraction time may accelerate chemical decomposition of syringin due to durative ultrasonic effect, which leads to the lower extraction yield [25]. Although ultrasound-assisted extraction has considerable potential in extraction fields of natural constituents, the flavor and composition of some edible oils is deteriorated after ultrasound treatment [26,27].…”

Section: Resultsmentioning

confidence: 99%

Ultrasound-Assisted Extraction of Syringin from the Bark of Ilex rotunda Thumb Using Response Surface Methodology

Zhao

Deng

et al. 2012

IJMS

Self Cite

View full text Add to dashboard Cite

In this work, a rapid extraction method based on ultrasound-assisted extraction (UAE) of syringin from the bark of Ilex rotunda Thumb using response surface methodology (RSM) is described. The syringin was analyzed and quantified by high performance liquid chromatography coupled with UV detection (HPLC-UV). The extraction solvent, extraction temperature and extraction time, the three main factors for UAE, were optimized with Box-Behnken design (BBD) to obtain the highest extraction efficiency. The optimal conditions were the use of a sonication frequency of 40 kHz, 65% methanol as the solvent, an extraction time of 30 min and an extraction temperature of 40 °C. Using these optimal conditions, the experimental values agreed closely with the predicted values. The analysis of variance (ANOVA) indicated a high goodness of model fit and the success of the RSM method for optimizing syringin extraction from the bark of I. rotunda.

show abstract

“…Box-Behnken design (BBD), as one of the RSM designs, is more efficient and easier to arrange and interpret experiments in comparison with others, and widely applied in many studies [20,21]. Our research team has employed this technology for the extraction of chromones in Radix Saposhnikoviae [22]. …”

Section: Introductionmentioning

confidence: 99%

Response Surface Methodology to Optimize Enzymatic Preparation of Deapio-Platycodin D and Platycodin D from Radix Platycodi

Zhao

Wang

et al. 2012

IJMS

Self Cite

View full text Add to dashboard Cite

In the present work, we reported the enzymatic preparation of deapio-platycodin D (dPD) and platycodin D (PD) optimized by response surface methodology (RSM) from Radix Platycodi. During investigation of the hydrolysis of crude platycosides by various glycoside hydrolases, snailase showed a strong ability to transform deapio-platycoside E (dPE) and platycoside E (PE) into dPD and PD with 100% conversion. RSM was used to optimize the effects of the reaction temperature (35–45 °C), enzyme load (5–20%), and reaction time (4–24 h) on the conversion process. Validation of the RSM model was verified by the good agreement between the experimental and the predicted values of dPD and PD conversion yield. The optimum preparation conditions were as follows: temperature, 43 °C; enzyme load, 15%; reaction time, 22 h. The biotransformation pathways were dPE→dPD3→dPD and PE→PD3→PD, respectively. The determined method may be highly applicable for the enzymatic preparation of dPD and PD for medicinal purposes and also for commercial use.

show abstract

Application of response surface methodology to optimise ultrasonic‐assisted extraction of four chromones in Radix Saposhnikoviae

Abstract: Under these optimal conditions, the experimental values agreed closely with the predicted values. The analysis of variance indicated a high goodness of model fit and the success of RSM method for optimising chromones extraction in Radix Saposhnikoviae.

Cited by 53 publications

References 31 publications

Evaluation of the Antioxidant Activity of Coreopsis Tinctoria Nuff. and Optimisation of Isolation by Response Surface Methodology

Evaluation of the Antioxidant Activity of Coreopsis Tinctoria Nuff. and Optimisation of Isolation by Response Surface Methodology

Ultrasound-Assisted Extraction of Syringin from the Bark of Ilex rotunda Thumb Using Response Surface Methodology

Response Surface Methodology to Optimize Enzymatic Preparation of Deapio-Platycodin D and Platycodin D from Radix Platycodi

Contact Info

Product

Resources

About