Application of Simplex Lattice Design Method on The Optimisation of Deodorant Roll-on Formula of Ashitaba (Angelica keiskei)

Abstract

Ashitaba is known to have antioxidant activity and gram-positive antibacterial activity that causes body odor. This is the potential activity for an active substance to be developed as deodorant. The appropriate formula is needed, so it is necessary to optimize the formula using the right method. This study aimed was to determine the application of the simplex lattice design method on the optimization of a deodorant roll-on formula of ashitaba extract. Ashitaba was extracted by the maceration method. The formula optimization design was determined using the simplex lattice design method by Design Expert®7.5.1. The components for optimization were the concentration of carbopol and concentration of TEA, and the optimization parameters were the spreadability test, sticky power, and pH test. The optimum formula of deodorant consists of 0.45% carbopol and 2.05% TEA. The responses of optimum formula obtained spreadability test 6.32 ± 0.33 cm, sticky power 44.67 ± 3.94 seconds, and pH 7.73 ± 0.17. These results meet the criteria for good preparation but need further testing related to the effectiveness of the preparation and the level of acceptance of the preparation by the user.

Optimization of Non-Effervescet Floating Tablets Ranitidine HCL Formula Using Durian Seed Matrix (Durio Zibethinus Murr) Fully Gelatinized Modified Using Simplex Lattice Design Method

“…The moist mass is then passed through a 10-mesh sieve to form granules. The moist mass is sieved with a mesh sieve I Gusti Ngurah Agung Dewantara Putra, Eka Indra Setyawan, Ni Putu Maya Ninditha, Made Tresia Pramasta Diva Optimization of Non-Effervescet Floating Tablets Ranitidine HCL For-mula Using Durian Seed Matrix (Durio Zibethinus Murr) Fully Gelati-nized Modified Using Simplex Lattice Design Method 2172 10 to increase the surface area of particles, making the drying process easier at a temperature of 40ºC-60ºC (Hajrin et al, 2021). The formed granules are dried using an oven at a temperature of 50ºC until the water content meets the requirements.…”