Application of surface-layer matrix-assisted laser desorption/ionization mass spectrometry imaging to pharmaceutical-loaded poly(ester urea) films

Williams-Pavlantos, Kayla; Brigham-Stinson, Natasha C.; Becker, Matthew L.; Wesdemiotis, Chrys

doi:10.1016/j.aca.2023.341963

Cited by 3 publications

(1 citation statement)

References 37 publications

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“…Substantial improvement is possible with MALDI lasers operating at frequencies ≥2 kHz, as compared to the ~100 Hz in the equipment of the studies reported thus far (Endres et al, 2018) due to markedly improved signal averaging. The current upper mass limit is around 20 kDa (Yao, 2014), making the SL‐MALDI‐MS method most suitable for the analysis of low to medium MW samples and of additives (such as drugs or unwanted contaminants) on the surface of very high‐mass polymers (Williams‐Pavlantos & Wesdemiotis, 2021).…”

Section: Analysis and Imaging Of Solid Polymer Surfacesmentioning

confidence: 99%

Mass spectrometry of polymers: A tutorial review

Wesdemiotis

Williams-Pavlantos

Keating

et al. 2023

Mass Spectrometry Reviews

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Ever since the inception of synthetic polymeric materials in the late 19th century, the number of studies on polymers as well as the complexity of their structures have only increased. The development and commercialization of new polymers with properties fine‐tuned for specific technological, environmental, consumer, or biomedical applications requires powerful analytical techniques that permit the in‐depth characterization of these materials. One such method with the ability to provide chemical composition and structure information with high sensitivity, selectivity, specificity, and speed is mass spectrometry (MS). This tutorial review presents and exemplifies the various MS techniques available for the elucidation of specific structural features in a synthetic polymer, including compositional complexity, primary structure, architecture, topology, and surface properties. Key to every MS analysis is sample conversion to gas‐phase ions. This review describes the fundamentals of the most suitable ionization methods for synthetic materials and provides relevant sample preparation protocols. Most importantly, structural characterizations via one‐step as well as hyphenated or multidimensional approaches are introduced and demonstrated with specific applications, including surface sensitive and imaging techniques. The aim of this tutorial review is to illustrate the capabilities of MS for the characterization of large, complex polymers and emphasize its potential as a powerful compositional and structural elucidation tool in polymer chemistry.

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Section: Analysis and Imaging Of Solid Polymer Surfacesmentioning

confidence: 99%

Mass spectrometry of polymers: A tutorial review

Wesdemiotis

Williams-Pavlantos

Keating

et al. 2023

Mass Spectrometry Reviews

View full text Add to dashboard Cite

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Pre‐Clinical Assessment of Bupivacaine‐Loaded Poly(ester urea) Thin Films for Controlled Drug Release and Effective Pain Management After Surgery

Stinson,

Matsuoka,

Agarwal

et al. 2024

Adv Healthcare Materials

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Safe, effective pain management remains one of the biggest challenges following surgical procedures. Despite widespread recognition of this problem and advances in the mechanistic understanding of pain signaling, post‐surgical pain is often undermanaged, with opioid use remaining the clinical standard. As an alternative to current oral, systemic treatments, a degradable bupivacaine‐loaded poly(ester urea) (PEU) thin film has been developed to deliver bupivacaine directly to the site of injury over an extended duration. The dose and duration of bupivacaine delivery is controlled using polymer composition and bupivacaine concentration. Systemic bupivacaine concentrations are more than an order of magnitude lower when delivered locally versus intravenous injection. Tissue analysis showed that the majority of bupivacaine is deposited into subcutaneous tissue directly surrounding the implant. Bupivacaine concentration in soft tissue around the implant are 30‐fold higher than plasma values, indicating that release from PEU implants remains localized. Bupivacaine‐loaded PEU films are assessed into two established mouse models for diabetic neuropathic pain and post‐surgical incisional pain. In each model, bupivacaine eluting PEU films effectively block pain for 3–5 days before returning to baseline levels without loss of motor function and without signs of neurotoxicity.

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Advances in solvent-free sample preparation methods for matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) of polymers and biomolecules

Williams-Pavlantos,

Wesdemiotis

2023

Advances in Sample Preparation

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Application of surface-layer matrix-assisted laser desorption/ionization mass spectrometry imaging to pharmaceutical-loaded poly(ester urea) films

Cited by 3 publications

References 37 publications

Mass spectrometry of polymers: A tutorial review

Mass spectrometry of polymers: A tutorial review

Pre‐Clinical Assessment of Bupivacaine‐Loaded Poly(ester urea) Thin Films for Controlled Drug Release and Effective Pain Management After Surgery

Advances in solvent-free sample preparation methods for matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) of polymers and biomolecules

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