Application of Taguchi method in the optimization of synthesis of cellulose-MgO bionanocomposite as antibacterial agent

Abstract

In this study, optimal conditions to form cellulose-MgO nanocomposite with antibacterial properties were evaluated. Applying the Taguchi method, 9 experiments were designed and the effects of different concentrations of biopolymers cellulose (0.5, 1 and 2 mg/ml), MgO nanoparticles (2, 4 and 8 mg/ml) and stirring times (30, 60 and 90 min) on antibacterial activity of synthesized nanocomposites were assessed. The characterizations of products were investigated by dynamic light scattering (DLS), raman spectroscopy, scanning electron microscope (SEM), thermogravimetric analysis (TGA) and differential thermal analysis (DTA). The results showed that the nanocomposite produced in the conditions of experiment 9 (MgO 8 mg/ml, cellulose 2 mg/ml and stirring time of 60 min) has the strongest antibacterial activity. The outcomes of both methods of colony forming units (CFU) and disc diffusion indicated that the antibacterial activity of cellulose-MgO nanocomposite was signifi cantly higher than its components (P <0.05). Thermal analysis indicated improvement in the thermal stability of the cellulose biopolymer after the formation of the nanocomposite. Due to the improvement of the antibacterial properties of cellulose-MgO nanocomposite compared to its components, we can use it as a new antibacterial agent in the fi elds of pharmaceutical, medicine and dentistry.

The Potential of Fe‐Based Magnetic Nanomaterials for the Agriculture Sector

“…MgO NPs have been reported to function as valid antimicrobial agents either through the sole application or combined usage with other antimicrobial compounds [257] owing to their special biological and enhanced antimicrobial properties. [258] Kong et al [259] disclosed that MgO NPs were effective to act as an antifungal agent against C. albicans.…”

Preparation of electrospun hybrid polyacrylonitrile nanofibers containing TiO2/Fe3O4 and their capsaicinoids adsorption applications

“…Consequently, membrane diameter in the fabrication of PAN/TiO 2 /Fe 3 O 4 composite nanofiber can be decreased using the Taguchi method. To date, Taguchi method has been used in various studies to optimize the preparation of diverse membranes for a variety of applications, including carbon molecular sieve for carbon dioxide adsorption, [ 28 ] cellulose‐MgO bionanocomposite as an antibacterial agent, [ 29 ] poly(acrylic acid)‐ZnO coated PVDF membrane for oily wastewater treatment, [ 30 ] carbon nanotubes for the adsorption of Pb(II) and Ni(II) from chemical industry wastewater, [ 31 ] and a porous ceramic membrane for removing of petroleum compounds and flux. [ 32 ]…”

Polymeric Dental Nanomaterials: Antimicrobial Action

“…However, like Ag NPs, they are prone to aggregation, which reduces the activity of nanoparticles against bacteria. Aggregation can be prevented by using cellulose, which provides a closer contact of nanoparticles with bacteria and thus bacterial growth can be inhibited by almost 100% [ 54 ].…”