Application of Tendon-Derived Stem Cell Sheet for the Promotion of Graft Healing in Anterior Cruciate Ligament Reconstruction

Lui, Pauline Po Yee; Wong, On Tik; Lee, Wayne

doi:10.1177/0363546513517539

Cited by 108 publications

(124 citation statements)

References 27 publications

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“…Supplementation with CTGF enriched a CD146 + TSPC subpopulation (likely derived from a perivascular source) and stimulated proliferation and tenogenic differentiation . This was consistent with several studies showing efficient tenogenic differentiation in TSPCs in parallel with downregulation of osteo‐, chondro‐, and adipogenic gene expression . In vivo delivery of CTGF also resulted in recruitment of CD146 + cells and improved tendon healing .…”

Section: Tspc Culture and Differentiation: Growth Factors Small Molesupporting

confidence: 86%

Tendon stem progenitor cells: Understanding the biology to inform therapeutic strategies for tendon repair

Walia

Huang

2018

Journal Orthopaedic Research

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Tendon and ligament injuries are a leading cause of healthcare visits with significant impact in terms of economic cost and reduced quality of life. To date, reparative strategies remain largely restricted to conservative treatment or surgical repair. However, these therapies fail to restore native tendon structure and function; thus, the tissue may re‐rupture or degenerate with time. To improve tendon healing, one promising strategy may be harnessing the innate potential of resident tendon stem/progenitor cells (TSPCs) to guide tenogenic regeneration. In this review, we outline recent advances in the identification and characterization of putative TSPC populations, and discuss biochemical, biomechanical, and biomaterial methods employed for their culture and differentiation. Finally, we identify limitations in our current understanding of TSPC biology, key challenges for their use, and potential therapeutic strategies to inform cell‐based tendon repair. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:1270–1280, 2019.

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Section: Tspc Culture and Differentiation: Growth Factors Small Molesupporting

confidence: 86%

Tendon stem progenitor cells: Understanding the biology to inform therapeutic strategies for tendon repair

Walia

Huang

2018

Journal Orthopaedic Research

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“…The results demonstrated that the cells derived from the cell sheets incorporated within the bone tunnel site and grafted tendon and that healing of the bone-tendon junction and the grafted tendon was significantly enhanced. Similarly, to promote early graft healing following ACL reconstruction in a rat model, Lui et al (47) wrapped a tendon-derived stem cell (TDSC) sheet around the ACL graft. At weeks 2, 6 and 12 after reconstruction, the TDSC group showed a time-dependent increase in tunnel bone mineral density and bone volume/total volume at the epiphyseal region of the tibial tunnel.…”

Section: Tendon Stem Cell Sheets For Tendon Tissue Engineeringmentioning

confidence: 99%

Application of the cell sheet technique in tissue engineering

Chen

Niu

et al. 2015

Biomedical Reports

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“…151 Tendon-derived stem cell sheets stimulated with CTGF promoted improved anterior cruciate ligament graft healing and biomechanics in vivo in rats, including improved osteointegration. 152 Similarly, cell sheets with CTGF and ascorbic acid enhanced biomechanical and histology-based outcomes at 8 weeks in an in vivo rat patellar tendon repair model. Further studies introducing CTGF and/or BMP growth factors with cells and biocompatible matrices will be important for defining the next generation of therapies for flexor tendon repair.…”

Section: Biologic Treatmentsmentioning

confidence: 96%

Cell and Biologic-Based Treatment of Flexor Tendon Injuries

Linderman

Gelberman

Thomopoulos

et al. 2016

Operative Techniques in Orthopaedics

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The two primary factors leading to poor clinical results after intrasynovial tendon repair are adhesion formation within the digital sheath and repair-site elongation and rupture. As the outcomes following modern tendon multi-strand repair and controlled rehabilitation techniques are often unsatisfactory, alternative approaches, such as the application of growth factors and mesenchymal stem cells (MSCs), have become increasingly attractive treatment options. Successful biological therapies require carefully controlled spatiotemporal delivery of cells, growth factors, and biocompatible scaffold matrices in order to simultaneously (1) promote matrix synthesis at the tendon repair site leading to increased biomechanical strength and stiffness and (2) suppress matrix synthesis along the tendon surface and synovial sheath preventing adhesion formation. This review summarizes recent cell and biologic-based experimental treatments for flexor tendon injury, with an emphasis on large animal translational studies.

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Application of Tendon-Derived Stem Cell Sheet for the Promotion of Graft Healing in Anterior Cruciate Ligament Reconstruction

Abstract: The TDSC sheet could potentially be used for the promotion of graft healing in ACL reconstruction.

Cited by 108 publications

References 27 publications

Tendon stem progenitor cells: Understanding the biology to inform therapeutic strategies for tendon repair

Tendon stem progenitor cells: Understanding the biology to inform therapeutic strategies for tendon repair

Application of the cell sheet technique in tissue engineering

Cell and Biologic-Based Treatment of Flexor Tendon Injuries

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