Application of the Cozart DDS system to postmortem screening of drugs of abuse in vitreous humor

Fernández, Amparo Arroyo; Amigó, Narciso; Carbone, Marica; Mora, Agustí; Pinto, Mariana; Beltrán, Joan; Gassó, Sergio

doi:10.1007/s11419-009-0071-4

Cited by 7 publications

(1 citation statement)

References 17 publications

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“…The removal of post-mortem tissue can be complicated by legislation or religious custom hence a rapid near-body screen that can provide an indication of the presence of drugs in a body could be beneficial. Emergency departments, drug treatment clinics and workplace drug testing programs already use near-body drug screening to determine an individual's recent drug use [4][5][6][7][8][9] but few reports describe the use of near-body methodologies for post-mortem drug screening.…”

Section: Introductionmentioning

confidence: 99%

Use of the Randox Evidence Investigator immunoassay system for near-body drug screening during post-mortem examination in 261 forensic cases

McLaughlin

Maskell

Pounder

et al. 2019

Forensic Science International

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Background This paper describes the performance of four Randox drug arrays, designed for whole blood, for the near-body analysis of drugs in a range of post-mortem body specimens. Methods Liver, psoas muscle, femoral blood, vitreous humor and urine from 261 post-mortem cases were screened in the mortuary and results were obtained within the time taken to complete a post-mortem. Specimens were screened for the presence of amfetamine, barbiturates,

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Section: Introductionmentioning

confidence: 99%

Use of the Randox Evidence Investigator immunoassay system for near-body drug screening during post-mortem examination in 261 forensic cases

McLaughlin

Maskell

Pounder

et al. 2019

Forensic Science International

View full text Add to dashboard Cite

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Mass Spectrometry Applications in Forensic Science

Smith

2010

Encyclopedia of Analytical Chemistry

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The role of mass spectrometry (MS) in forensic science can be characterized as either molecular or elemental analysis. Relatively small, volatile, nonpolar molecules found in a variety of forensic samples can be analyzed with electron and chemical ionization (CI) routinely coupled with single‐stage mass analyzers that provide molecular weight and structural information. Nonvolatile and polar molecules including drugs, poisons, and/or their metabolites routinely found in biological matrices along with other analytes of forensic interest can be determined using electrospray or related soft ionization techniques coupled to tandem mass analyzer systems to identify a molecule through structure elucidation and provide excellent screening and quantitative results. New ambient ionization sources now allow the direct analysis of molecules from a forensic sample surface, with minimal prior preparation or separation. In addition, the sequencing of deoxyribonucleic acid (DNA) has also been difficult with most ionization sources until matrix‐assisted laser desorption ionization (MALDI), which has the potential to provide quick and dependable results, was utilized. Elemental profiles also provide reliable methods for characterizing and distinguishing forensic samples. This article aims at providing information about MS and its uses in the field of forensic science.

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Mass Spectrometry Applications in Forensic Science

Smith

Tran

2019

Encyclopedia of Analytical Chemistry

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Mass spectrometry (MS) is a technique widely used in forensic science for the identification of molecular or elemental composition of submitted evidence. Relatively small, volatile, nonpolar molecules, such as ignitable liquids and some drugs, can be analyzed with electron and chemical ionization (CI) coupled with single‐stage mass analyzers that provide molecular weight and structural information. Nonvolatile and polar molecules such as other drugs, poisons, and/or their metabolites can be identified using electrospray or related soft ionization techniques. The use of tandem MS with these compounds allows structure elucidation and provides excellent screening and quantitative results. Ambient ionization sources allow sampling directly from a surface with minimal sample preparation required. Elemental profiles also provide reliable methods for distinguishing between forensic samples. This article aims to provide an overview of the MS instrumentation, techniques, and applications within the field of forensic science.

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Application of the Cozart DDS system to postmortem screening of drugs of abuse in vitreous humor

Cited by 7 publications

References 17 publications

Use of the Randox Evidence Investigator immunoassay system for near-body drug screening during post-mortem examination in 261 forensic cases

Use of the Randox Evidence Investigator immunoassay system for near-body drug screening during post-mortem examination in 261 forensic cases

Mass Spectrometry Applications in Forensic Science

Mass Spectrometry Applications in Forensic Science

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