Application of the HPLC Method in Parenteral Nutrition Assessment: Stability Studies of Ondansetron

Abstract

Ondansetron (OND) is a serotonin type 3 receptor antagonist that exhibits antiemetic activity. From the clinical point of view, vomiting and nausea prevention is an important task. Anticancer treatment and recovery impact the patient’s overall state by affecting appetite, well-being, and physical activity, and consequently, nutrition quality. Depending on the patient’s indication and condition, parenteral nutrition is administered to meet full nutritional requirements. In addition, antiemetic drugs can be added to the parenteral nutrition (PN) admixture to treat chemo- or radio-therapy-induced nausea and vomiting. However, adding any medication to the PN admixture can result in the instability of the composition in the overall admixture. This study aimed to develop the HPLC method of determination of OND in Lipoflex special, one of the most popular, ready-to-use PN admixtures. The proposed HPLC method and the sample preparation procedure were suitable for analyzing OND in PN admixture stored under various conditions, such as exposure to sunlight and temperature. It was found that the decomposition of OND during the seven-day storage did not exceed 5% and did not depend on external factors. Based on the conducted research, it is recommended to add OND to Lipoflex special, and it is possible to store such an admixture for seven days.

Antiemetic Drugs Compatibility Evaluation with Paediatric Parenteral Nutrition Admixtures

“…So far, the compatibility data of antiemetics and PNA are scarce and often conflicting. Ondansetron has been proven to destabilise lipid emulsion with oiling out [ 16 ], but in contrast, OND’s compatibility has been confirmed by other researchers [ 17 , 18 , 19 ]. Staven et al [ 20 ] confirmed the compatibility of ondansetron and dexamethasone with ready-to-use PNAs, namely Numeta G16E and Olimel N5E.…”

“…The literature data show that adding drugs to PNAs influenced changes in the zeta potential. Differences depend on the added drugs: Ondansetron [ 18 ] caused a decrease in absolute value zeta potential. Contrarily, adding sodium valproate [ 33 ] to the PNAs caused its increase.…”

Stability and Compatibility Aspects of Drugs: The Case of Selected Cephalosporins

“…Interaction studies between drugs and reconstitution fluids or PN admixture can be studied in two different protocols. The first one is the addition of the reconstituted drug to infusion fluids to store for a longer time [20][21][22][23][24][25][26] or, in the case of PN admixture, the use of such medium as a drug carrier [27][28][29][30][31][32]. The second study protocol assumes administering two infusion drugs through the same infusion set using a Y-site connector [11,[33][34][35][36][37].…”