“…Zhou, Yan, & Hao, 2012;Weiqiang Zhou & Yan, 2010. In addition, α-Shape have equally been engaged in studying structures in proteins (Cheng & Shi, 2009;De-Alarcón, Pascual-Montano, Gupta, & Carazo, 2002;Pérot, Sperandio, Miteva, Camproux, & Villoutreix, 2010;Rohs et al, 2009;Wilson, Bender, Kaya, & Clemons, 2009), surface area and volume (J Liang, Edelsbrunner, Fu, Sudhakar, & Subramaniam, 1998;Lou, Jiang, Scott, & Paul, 2013;Nikkilä, Polishchuk, & Krasnoshchekov, 2014;Pesaresi & Schwingshackl, 2014), pockets (H Edelsbrunner, Facello, & Liang, 1998, as well as www.ccsenet.org/mas…”