Application of thermal analysis and pyrolysis coupled to GC/MS in the qualification of simvastatin pharmaceutical raw material

Procópio, José Valdilânio Virgulino; Souza, Valmir Gomes De; Costa, Rodrigo Alves; Correia, Lidiane Pinto; Souza, Fábio Santos de; Macêdo, Rui Oliveira

doi:10.1007/s10973-010-1274-y

Cited by 24 publications

(9 citation statements)

References 9 publications

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“…10,11,13,14 Thermogravimetry experiments carried out at 10 K/min indicate that after fusion SV undergoes pyrolysis with onset at approximately 443 or 476 K in dynamic air or dynamic N 2 atmospheres, respectively. 10,23 In this work, a comprehensive experimental study of the thermal stability of SV under different atmospheres with identification of the major degradation products is reported. In addition to isothermal tests carried out in glass ampules, dynamic and isothermal experiments were also carried out by differential scanning calorimetry (DSC) and Calvet-drop microcalorimetry, respectively.…”

Section: Introductionmentioning

confidence: 99%

Thermal Stability of Simvastatin under Different Atmospheres

Simões

Diogo

Dias

et al. 2014

Journal of Pharmaceutical Sciences

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Section: Introductionmentioning

confidence: 99%

Thermal Stability of Simvastatin under Different Atmospheres

Simões

Diogo

Dias

et al. 2014

Journal of Pharmaceutical Sciences

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“…4i) occurred at 400°C. Other authors also used DSC coupled to a photovisual system [22][23][24][25] and confirmed the parameters obtained by DSC and TG. This technique is an important tool to confirm events in special melting.…”

Section: Resultsmentioning

confidence: 55%

“…The structures of guanylhydrazones studied in this study are the following: Thermogravimetry (TG) and differential scanning calorimetry (DSC) are thermal techniques widely distributed and used in pharmaceutical analyses. These techniques are used in studies of drug characterization, purity, compatibility studies, polymorphism identification, stability evaluation, thermal decomposition of drugs, and development of pharmaceutical formulations [19][20][21][22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Thermal characterization of some guanylhydrazones by thermal and nonthermal techniques

galvão

Brito

Dantas

et al. 2014

J Therm Anal Calorim

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2-[(3,5-di-tert-butyl-4-hydroxyphenyl)methylene]-hydrazinecarboximidamide (WE010), 2-([1,1 0 -biphenyl]-4-ylmethylene)-hydrazinecarboximidamide (WE014), and 2-[(3,4-dichlorophenyl)methylene]-hydrazinecarboximidamide (WE017) are guanylhydrazone derivatives widely studied biologically and chemically; however, there are no studies regarding their thermal behaviors. The present study aims to apply the thermal analyses: differential scanning calorimetry (DSC), differential scanning calorimetry coupled to the photovisual system (DSC-photovisual), and thermogravimetry (TG), to characterize the guanylhydrazones, as well as HPLC and FTIR. The DSC curve of WE010 shows a melting process with T onset at 190°C and peak at 193.5°C (DH 41.0 J g -1 ). Due to the symmetry of the melting peaks obtained by DSC, it is possible to calculate the purity of the sample (98.87 %). The DSC curve of WE014 shows the melting process in the range of 208-213°C, with a melting peak at 211°C (DH 61 J g -1 ).The DSC curve of WE017 showed T onset at 215°C and peak temperature of 219°C (DH 55 J g -1 ). The TG curve of WE010, WE014, and WE017 presents initial decomposition temperatures of 186.95, 197.31, and 195.44°C, respectively. The DSC-photovisual confirmed the results of DSC and TG. The HPLC determined the purities of the samples and confirmed the results of DSC. The FTIR confirmed the thermal data. Thus, the use of thermal analysis is an important tool for the characterization of molecules with therapeutic potential contributing to the characterization and evaluation of their stability as well as nonthermal technique with complementary tool.

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“…Herbal medicine powder, its products and extracts have been characterized by analytical methods. Scanning electron microscopy (SEM) is used to characterize the morphology and particle size of herbal medicine powder [12,13]; thermal analysis such as thermogravimetry (TG) and differential thermal analysis (DTA) together with pyrolysis coupled to gas chromatography/mass spectrometry is employed to evaluate the quality of pharmaceuticals [14][15][16], as well as atomized extracts of herbal medicine like E. mulungu [17] and distinct brands and batches of Cymbopogon citratus teas [18]. Figure 1 shows the micrographs from samples CAR 01, 02 and 03.…”

Section: Thermal Decomposition Kinetic Interpretationmentioning

confidence: 99%

Herbal medicine physical quality evaluation by thermal analysis using adapted Ozawa method

Correia

Procópio

Santana

et al. 2015

J Therm Anal Calorim

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The aim of this study was to evaluate the physical quality of Tabebuia caraiba (Mart.) Bur. powder, separately in three batches of different particle sizes, through the adapted Ozawa method. The Ozawa model was used for thermogravimetry (TG) data analysis in dynamic synthetic air and nitrogen atmospheres in different heating rates (5, 10, 20 and 40°C min -1 ). The software TA-50 was used to data treatment. Kinetic data showed different values of activation energy and same reaction order according to the particle powder sample size in a specific model (derivative or tangent) of data treatment. The difference factor (F 1 ) was used to compare the parallelism line of the samples constructed by Ozawa graphs. Different kinetic results discriminate the particles size of the samples. TG technique allowed discriminating different particle sizes of herbal medicine powder.

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Application of thermal analysis and pyrolysis coupled to GC/MS in the qualification of simvastatin pharmaceutical raw material

Cited by 24 publications

References 9 publications

Thermal Stability of Simvastatin under Different Atmospheres

Thermal Stability of Simvastatin under Different Atmospheres

Thermal characterization of some guanylhydrazones by thermal and nonthermal techniques

Herbal medicine physical quality evaluation by thermal analysis using adapted Ozawa method

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