Application of thrombin-antithrombin III complex for detecting a latent hypercoagulable state in patients with coronary artery disease.

Uno, Masashi; Tsuji, Hajime; Watanabe, Masahiko; Takada, Osamu; Kobayashi, Kyoichiro; Takabuchi, Hiroaki; Shirai, Kaori; Sawada, Shohei; Toyoda, Takeo; Yamamoto, Katsumi; Katoh, Kazuharu; Nakagawa, Masao

doi:10.1253/jcj.53.1185

Cited by 14 publications

(5 citation statements)

References 20 publications

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“…Further direct clinical evidence linking physical exercise with TG was found in this study, showing that exercise training not only influences the hemostatic system per se, but also leads to significant TG and fibrin formation independent of the type of physical activity [171]. However, other investigators found no evidence that exercise training affects F 1+2 , but enhances TAT and fibrinopeptide A release [172][173][174], and that these changes could not be attributed solely to aspirin pretreatment during the repeated exercise [174]. Interestingly, one study did not support the hypothesis that myocardial ischemia, silent or symptomatic, is associated with enhanced TG that can be distinguished from exercise-induced TG [175].…”

Section: Markers Of Tgsupporting

confidence: 47%

Biomarkers and Exercise Training: A Possible Missing Link between Physical Activity and Mortality Benefit in Patients with Heart Failure

Serebruany¹,

Davis

Meister

et al. 2001

Heart Drug

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Knowledge of the pathogenesis of congestive heart failure (CHF) has improved greatly in recent years. Nevertheless, this disease still causes high morbidity and mortality in the Western world. In particular, there have been many advancements in our understanding, treatment and prophylaxis of CHF in recent years, yet the incidence of this disease continues to rise. Due to the staggering numbers of patients afflicted, CHF is becoming the most expensive burden on the health care system. The relationship between the deterioration of cardiac function and ongoing ischemic events has not been fully investigated and could conceivably be both monitored and modulated via various biomarkers. Recent data also indicate that heart failure is associated with altered hemostasis, i.e. a prothrombotic state which can lead to complications arising from occlusive and/or thromboembolic phenomena. Although the incidence of overt and clinically apparent thrombotic events is low, it is possible that subclinical events contribute to the increasing morbidity and mortality from this disease. These subclinical events may include silent ischemic events or microinfarcts which are being recognized as contributing to the progression of heart failure. As far as nonpharmacologic approaches to heart failure are concerned, the use of uniform exercise training regimens in heart failure is still a very controversial topic. Before more definitive recommendations can be made regarding the justification of such procedures, further large-scale studies investigating the effects of physical exercise on the development and progression of heart failure are needed. Furthermore, these studies must have sufficient statistical power to detect effects on clinical outcomes, specifically mortality. The purpose of this review article is to bridge the gap between biomarkers, exercise training and heart failure by discussing our current knowledge of different markers of platelet activation, thrombin generation, inflammation, endothelial dysfunction and myocardial necrosis in CHF patients undertaking physical exercise.

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Section: Markers Of Tgsupporting

confidence: 47%

Biomarkers and Exercise Training: A Possible Missing Link between Physical Activity and Mortality Benefit in Patients with Heart Failure

Serebruany¹,

Davis

Meister

et al. 2001

Heart Drug

View full text Add to dashboard Cite

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“…In our study, the plasma units had TAT complex within the normal range. In a study of 50 volunteers, a mean TAT value of 2.1 m g per L (range, 1.1-7.5 m g/L) was found, while in patients undergoing disseminated intravascular coagulation the mean value reached 15.8 m g per L, and in patients with deep-vein thrombosis, the value reached 9.4 m g per L. 31 After submaximal exercise, TAT rose from 1.49 m g per L to 12.07 m g per L. 32 Therefore, no thrombin generation took place during the plasma collection procedures. Content in D-dimer, which would reveal ongoing thrombus formation and lysis, 33 was low in all plasma units showing no sign of fibrin formation or fibrinolysis.…”

Section: Discussionmentioning

confidence: 95%

“…In a study of 50 volunteers, a mean TAT value of 2.1 µg per L (range, 1.1‐7.5 µg/L) was found, while in patients undergoing disseminated intravascular coagulation the mean value reached 15.8 µg per L, and in patients with deep‐vein thrombosis, the value reached 9.4 µg per L 31 . After submaximal exercise, TAT rose from 1.49 µg per L to 12.07 µg per L 32 . Therefore, no thrombin generation took place during the plasma collection procedures.…”

Section: Discussionmentioning

confidence: 97%

Protein composition and activation markers in plasma collected by three apheresis procedures

et al. 2003

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“…As a marker of assessing the level of coagulation activation, increased levels of TAT were observed in patients with coronary artery disease, peripheral arterial occlusive disease, or perioperative patients associated with the development of DVT. 13 – 16 Plasmin-α2-plasmin inhibitor complex, an irreversible complex of plasmin and a2-plasmin inhibitor, is considered as a satisfactory indicator of an enhanced fibrinolytic state in vivo because it is almost undetectable in normal persons and expected to be more useful for the clinical assessment of VTE in patients with a high-risk perioperative VTE. 17 , 18 Besides, t-PAIC, the 1:1 covalent inactive complex of tPA and PAI-1, has been proposed as a marker of the fibrinolytic system in the diagnosis of acute myocardial infarction (MI), stroke, and VTE.…”

Section: Introductionmentioning

confidence: 99%

Changes in Biomarkers of Coagulation, Fibrinolytic, and Endothelial Functions for Evaluating the Predisposition to Venous Thromboembolism in Patients With Hereditary Thrombophilia

Gao

et al. 2020

Clin Appl Thromb Hemost

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The changes in the coagulation, fibrinolytic, and endothelial functions are correlated with the pathophysiology of the thromboembolic diseases during acute illness. However, these changes in patients with hereditary thrombophilia who were not in the acute stage of venous thromboembolism (VTE) are unclear. A panel of 4 biomarkers, including thrombin–antithrombin complex (TAT), plasmin-α2-plasmin inhibitor complex (PIC), tissue-type plasminogen activator/plasminogen activator inhibitor-1 complex (t-PAIC), and soluble thrombomodulin (sTM), were assayed in 100 healthy controls and 100 patients with thrombophilia. Although significantly higher concentrations of TAT, PIC, t-PAIC, and sTM were observed in patients with thrombophilia than in healthy controls, 70 patients showed absolutely normal levels of the above 4 biomarkers. Among the other 30 patients who had at least 1 biomarker out of the corresponding reference interval, 26 of them presented elevated PIC with or without increased TAT. Except for sTM, other 3 biomarkers did not show significant differences in patients with previous VTE compared to those without. Patients with single episode of VTE had obviously lower t-PAIC than those with multiple episodes of VTE, whereas the levels of TAT, PIC, and sTM were unassociated with the number of thrombosis episodes. Most thrombophilia patients who were not in the acute stage of VTE showed normal coagulation, fibrinolytic, and endothelial functions. Thus, we were unable to show that the one-time response of this panel was clinically helpful in determining thrombosis risk in thrombophilia individuals. Future studies should focus on the dynamic monitoring during the chronic phase of VTE to offer special advantages for patients with thrombophilia.

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Application of thrombin-antithrombin III complex for detecting a latent hypercoagulable state in patients with coronary artery disease.

Cited by 14 publications

References 20 publications

Biomarkers and Exercise Training: A Possible Missing Link between Physical Activity and Mortality Benefit in Patients with Heart Failure

Biomarkers and Exercise Training: A Possible Missing Link between Physical Activity and Mortality Benefit in Patients with Heart Failure

Protein composition and activation markers in plasma collected by three apheresis procedures

Changes in Biomarkers of Coagulation, Fibrinolytic, and Endothelial Functions for Evaluating the Predisposition to Venous Thromboembolism in Patients With Hereditary Thrombophilia

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