Application of thymine-based nucleobase-modified acrylamide as a functional co-monomer in electropolymerised thin-film molecularly imprinted polymer (MIP) for selective protein (haemoglobin) binding

EL-Sharif, Hazim F.; Turner, Nicholas W.; Reddy, Subrayal M.; Sullivan, Mark V.

doi:10.1016/j.talanta.2021.123158

Cited by 17 publications

(3 citation statements)

References 52 publications

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“…[176] The downside of "in-situ spinning" being that the deposited layer is not highly crosslinked, which is normally definitive of MIPs as this instills rigidity and receptor stability. This said, strong ionic interactions stabilized by a template species have the potential to mimic this highly Further examples: [147][148][149][150][151][152][153] crosslinked characteristic and fibers spun have mimetic capabilities, or post crosslinking of the polymer are a possibility. [177] Huang et al highlight this approach as they form nanofiber films for the sensitive detection of 2,4,6-tribromophenol (TDP) by spin coating a solution containing TDP alongside the monomer 𝛽cyclodextrin (𝛽-CD) and poly-vinylbutyral (PDB) as electrospinning matrix.…”

Section: Electrospinningmentioning

confidence: 99%

Deposition Methods for the Integration of Molecularly Imprinted Polymers (MIPs) in Sensor Applications

Caldara

Wissen

Cleij

et al. 2023

Advanced Sensor Research

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Offering high specificity and selectivity, molecularly imprinted polymers (MIPs) are synthetic polymeric affinity reagents that have become increasingly popular over the last couple of decades. Due to their long-term chemical and physical stability and low production cost, they have become an increasingly popular choice of receptor in the realm of sense. MIPs have therefore been associated with the detection of small molecules, proteins, cells, and pathogens, proving a highly robust and useful tool in the production of next-gen sensing platforms. This said, the development of these sensors pivots on one simple fact; these receptors have to be deposited onto a substrate for their desired application. The deposition of MIPs during sensor fabrication is therefore of great importance, with the field utilizing an array of mechanical and chemical deposition methods to achieve this. To this end, this review, therefore, sets aim at coalescing these different deposition approaches, classifying them, and outlining their utility when it comes to receptor design and integration. Thus, offering a knowledge base on current deposition methods, potential future approaches and analyzing where the MIP deposition field is tending toward.

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Section: Electrospinningmentioning

confidence: 99%

Deposition Methods for the Integration of Molecularly Imprinted Polymers (MIPs) in Sensor Applications

Caldara

Wissen

Cleij

et al. 2023

Advanced Sensor Research

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“…For better template removal, non-covalent interactions such as hydrogen bonds are preferable. Currently, frequently used functional monomers for MIPs synthesis include 3-aminophenylboronic acid [ 20 ], resorcinol [ 21 ], methacrylic acid [ 22 ], 4-aminothiophenol [ 23 ], chitosan [ 24 ], and acrylamide [ 25 ]. What these monomers have in common is that they have special functional groups that could afford sufficient binding sites with the template through non-covalent interaction (e.g., hydrogen bonds, electrostatic, and/or π–π interactions).…”

Section: Introductionmentioning

confidence: 99%

Rapid and Sensitive Detection of Sulfamethizole Using a Reusable Molecularly Imprinted Electrochemical Sensor

Kong

et al. 2023

Foods

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Efficient methods for monitoring sulfonamides (SAs) in water and animal-source foods are of great importance to achieve environmental safety and protect human health. Here, we demonstrate a reusable and label-free electrochemical sensor for the rapid and sensitive detection of sulfamethizole based on an electropolymerized molecularly imprinted polymer (MIP) film as the recognition layer. To achieve effective recognition, monomer screening among four kinds of 3-substituted thiophenes was performed by computational simulation and subsequent experimental evaluation, and 3-thiopheneethanol was finally selected. MIP synthesis is very fast and green, and can be in situ fabricated on the transducer surface within 30 min in an aqueous solution. The preparation process of the MIP was characterized by electrochemical techniques. Various parameters affecting MIP fabrication and its recognition response were investigated in detail. Under optimized experimental conditions, good linearity in the range of 0.001−10 μM and a low determination limit of 0.18 nM were achieved for sulfamethizole. The sensor showed excellent selectivity, which can distinguish between structurally similar SAs. In addition, the sensor displayed good reusability and stability. Even after 7 days of storage, or being reused 7 times, higher than 90% of the initial determination signals were retained. The practical applicability of the sensor was also demonstrated in spiked water and milk samples at the nM determination level with satisfactory recoveries. Compared to relevant methods for SAs, this sensor is more convenient, rapid, economical, and eco-friendly, and had comparable or even higher sensitivity, which offered a simple and efficient method for SA detection.

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“…To date, the free radical polymerization of water-soluble acrylic monomers is still the most common method for the synthesis of PIPs. [32][33][34] The affinity of PIPs for proteins generally comes from the hydrogen bonding, electrostatic interactions and hydrophobic interactions between these functional monomers and the template proteins. [35][36][37] Unfortunately, traditional free radical polymerization will not contribute to enhance these special noncovalent interactions between PIPs and proteins.…”

Section: Introductionmentioning

confidence: 99%

Functional thiolactone assisted imprinting cavities with abundant amines for strong binding of protein imprinted nanospheres

Wang

Zhou²,

Zhang

et al. 2023

J. Mater. Chem. B

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Application of thymine-based nucleobase-modified acrylamide as a functional co-monomer in electropolymerised thin-film molecularly imprinted polymer (MIP) for selective protein (haemoglobin) binding

Cited by 17 publications

References 52 publications

Deposition Methods for the Integration of Molecularly Imprinted Polymers (MIPs) in Sensor Applications

Deposition Methods for the Integration of Molecularly Imprinted Polymers (MIPs) in Sensor Applications

Rapid and Sensitive Detection of Sulfamethizole Using a Reusable Molecularly Imprinted Electrochemical Sensor

Functional thiolactone assisted imprinting cavities with abundant amines for strong binding of protein imprinted nanospheres

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