Application of X-Ray Powder Diffraction for Analysis of Selected Dietary Supplements Containing Magnesium and Calcium

Abstract

It is estimated that ∼50% of medications and dietary supplements offered in the Internet are counterfeit. X-ray diffraction is one of the techniques which may be successfully applied to identify various chemical compounds in polycrystalline mixtures such as dietary supplements, but also medications, narcotics or designer drugs. X-ray diffraction enables the understanding of compositions of such mixtures. For the tests, 22 dietary supplements which should contain magnesium and calcium compounds, available in pharmacies, groceries, Internet shops, as well as in shops for sportspersons, were selected. Identification of crystalline substances present in the tested sample consists in determination of inter-planar distances d hkl of investigated substances and determination of intensity of the obtained diffraction lines, and then in comparing them with values contained in diffraction databases. In this study, the ICDD-PDF2 database was used. The most important criterion in qualitative analysis, confirming the presence of a given phase, is the conformity of positions of diffraction lines in the recorded diffraction image with those in the reference image. Reflection shifts for the individual 2θ angles compared with the data from the database should not exceed 0.2 •. In most cases, X-ray analysis of the investigated dietary supplements proved the presence of magnesium and calcium compounds declared by the manufacturer, as well as allowing the identification of auxiliary substances present in the tested products. In the case of two magnesium-containing dietary supplements, the magnesium compounds declared by the manufacturer were not found. Our studies confirmed the effectiveness of X-ray structural analysis and proved the possibility of distinguishing counterfeit preparations from authentic products, as well as to use this method for the quality control of such pharmaceutical preparations.

The Usefulness of X-ray Diffraction and Thermal Analysis to Study Dietary Supplements Containing Iron

“…Therefore, fast and efficient methods for evaluating OIS ingredients are needed to assess quality and safety; ideally, solid-state analytical techniques avoid any changes in composition during the analysis. This work continues our previous works focusing on the examination of dietary supplements and drugs using X-ray powder diffraction (XRPD) and differential scanning calorimetry (DSC) [ 26 , 27 ]. This work aimed to identify iron compounds declared by the manufacturer as food supplements and to determine whether the product meets the manufacturer’s claims.…”

X-ray and Thermal Analysis of Selected Drugs Containing Acetaminophen

“…Additional lines, lack of lines, as well as line shifts will be observed in diffraction patterns of counterfeit products. Qualitative phase analysis may be used successfully as technique allowing for distinguishing of authentic pharmaceutics from counterfeit products [ 20 , 21 ].…”

Simulación de perfiles de difracción de rayos X de muestras problema para aplicaciones académicas

“…La difracción de Rayos X es usualmente incluida como un tópico de alta importancia en las asignaturas de Química analítica que se les imparte a profesiones como la Química, Geología, Ingeniería Geológica, Farmacéutica, entre otras (Jendrzejewska, 2020). Como parte inicial de un curso básico de difracción de rayos X, generalmente se aborda el fundamento de la técnica, el modo de operación del equipo y las posibles aplicaciones que ofrece esta técnica analítica (Ali et al, 2022;Bunaciu et al, 2015;Skoog et al, 2014).…”