Application Value of Combined Detection of NLR, PNI, D-Dimer, CD3+ T Lymphocytes, and CEA in Colorectal Cancer Screening

Ding, Rui; Chen, Zheng; He, Ming; Cen, Hong; Liu, Zehui; Su, Yonghui

doi:10.1155/2022/7913025

Cited by 9 publications

(2 citation statements)

References 30 publications

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“…Studies show that the cancer antigen (CA 15.3) is used to monitor response to breast cancer treatment and disease recurrence, although the diagnostic threshold varies according to the laboratory and the kit used, data from the present study corroborate with those found in the literature, where we observed a high incidence of breast cancer in women, although CA 15.3 has not been used specifically for breast cancer screening, it can be implemented to reduce costs and high risks with mammography at these ages. A recent study showed that the combination of neutrophil lymphocytes (NLR), prognostic nutritional index (PNI), D-dimer (D-D), CD3+ T lymphocytes (CD3+ T) and CEA has a high clinical application value for colorectal cancer and can provide a reference for early screening and auxiliary diagnosis of colorectal cancer [60]. CEA is the most widely used tumor marker for clinical screening and diagnosis of colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

Cancer Screening in Angolan Individuals Using Tumor Marker Tests at Mediag, Luanda-Angola

Cassinela,

Quixari,

Silveira

et al. 2023

Preprint

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Tumor biomarkers have great potential in screening and their role could extend further from general population risk assessment to treatment response estimation and recurrence monitoring. Different molecular and cellular elements in blood, which give information about the status of an individual, make it a perfect compartment to develop noninvasive diagnostics approaches for cancer. The present study aimed to screen the most frequent tumor markers in the Angolan population according to age and gender. A whole blood sample was collected for each patient. Serum levels were measured using the electrochemiluminescence method, using the automated Cobas e411 equipment (Roche®) according to the manufacturer's instructions. The results of our study elucidated the relevance of tumor biomarkers in screening for different types of cancer. These results also highlight the robustness of the mean in suspected cases, which is 15 to 17 times higher in some markers than in non-suspected cases. More research is needed to elucidate the relevance of these biomarkers in the Angolan population.

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Section: Discussionmentioning

confidence: 99%

Cancer Screening in Angolan Individuals Using Tumor Marker Tests at Mediag, Luanda-Angola

Cassinela,

Quixari,

Silveira

et al. 2023

Preprint

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“…For this reason, D-dimers have been found to reflect fibrinolysis and activation of the coagulation cascade. For example, studies have shown that D-dimer can be used as a prognostic marker for tumor indications in colorectal, 12 lung, 13 liver, 14 ovary, 15 and gastric cancer progression. 16 The platelet count is another widely used marker that can be easily obtained from the parameters of whole blood cells.…”

Section: Introductionmentioning

confidence: 99%

A Nomogram Combining Neutrophil-to-Lymphocyte Ratio and D-Dimer Predicts Chemosensitivity of Oxaliplatin-Based First-Line Chemotherapy in Patients with Unresectable Advanced Gastric Cancer

Shen

et al. 2022

Technol Cancer Res Treat

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Introduction: No effective peripheral blood predictors have been establoshed for first-line chemotherapy in patients with advanced gastric cancer. In this study, a nomogram combining the neutrophil-to-lymphocyte ratio/D-dimer with gender, number of metastases, and histological grade was established to predict progression-free survival in patients with unresectable advanced gastric cancer. Methods: We retrospectively collected baseline clinical characteristics and blood parameters from 153 patients diagnosed with advanced gastric cancer that underwent oxaliplatin-based first-line chemotherapy. Kaplan–Meier analysis and Cox regression analysis were used to determine the factors associated with progression-free survival. The concordance index (C-index) and calibration curve were used to determine the prediction accuracy and discriminative ability of the nomogram as a visual complement to the prognostic score system. Results: Determined by the X-tile software, the optimal cut-off points for the neutrophil-to-lymphocyte ratio and D-dimer were 3.18 and 0.56 mg/L, respectively. Multivariate analysis identified four independent prognostic factors: two or more metastatic organs (HR: 1.562, 95% CI: 1.009-2.418, P = .046), poor differentiation (HR: 0.308, 95% CI: 0.194-0.487, P < .001), neutrophil-to-lymphocyte ratio >3.18 (HR: 1.427, 95% CI: 1.024-1.989, P = .036), and D-dimer >0.56 mg/L (HR: 1.811, 95% CI: 1.183-2.773, P = .006). Receiver operating characteristic curves showed that the combination of the neutrophil-to-lymphocyte ratio and D-dimer in the prediction model exhibited the highest predictive performance (area under the curve, 0.800). The prognostic nomogram yielded a C-index of 0.800. Decision curve analysis demonstrated that the prognostic nomogram was clinically useful. A nomogram-based risk classification system was also constructed to facilitate risk stratification of advanced gastric cancer for optimal clinical management. Conclusion: We identified the neutrophil-to-lymphocyte ratio and D-dimer level as independent prognostic factors for advanced gastric cancer. The prognostic nomogram combining the neutrophil-to-lymphocyte ratio and D-dimer level can be applied in the individualized prediction of treatment outcome in patients with advanced gastric cancer.

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Prognostic Nutritional Index is Related to All‐Cause Mortality in Patients With Stage IV Colorectal Cancer Treated With Capecitabine: Single‐Center 24‐Month Observational Study in Vietnam

Nguyen Quang,

Nguyen Duc,

Hoang Van

et al. 2024

Clinical Laboratory Analysis

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AimTo determine the mortality rate and the predictive value of the prognostic nutritional index (PNI) for all‐cause mortality during the 24 months in patients with stage IV colorectal cancer treated with capecitabine.MethodsWe conducted a study on 87 stage IV colorectal cancer patients treated with capecitabine. Before the day of treatment, all patients were measured CEA and CRP‐hs levels and calculated neutrophil/lympho ratio (NLR) and PNI. Patients were monitored and collected drug side effects and mortality for 24 months.ResultsThe mortality rate of study subjects was 60.9%. CRP‐hs, NLR, and PNI were independent factors associated with 24‐month mortality in patients with stage IV colorectal cancer (p < 0.05 to p < 0.01). At a cut‐off value of 38.51, PNI was a predictor for mortality, with the area under the curve (AUC) of 0.88 and p < 0.001.ConclusionsPNI was a good predictor of all‐cause mortality in patients with stage IV colorectal cancer treated with capecitabine for 24 months.

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Application Value of Combined Detection of NLR, PNI, D-Dimer, CD3+ T Lymphocytes, and CEA in Colorectal Cancer Screening

Cited by 9 publications

References 30 publications

Cancer Screening in Angolan Individuals Using Tumor Marker Tests at Mediag, Luanda-Angola

Cancer Screening in Angolan Individuals Using Tumor Marker Tests at Mediag, Luanda-Angola

A Nomogram Combining Neutrophil-to-Lymphocyte Ratio and D-Dimer Predicts Chemosensitivity of Oxaliplatin-Based First-Line Chemotherapy in Patients with Unresectable Advanced Gastric Cancer

Prognostic Nutritional Index is Related to All‐Cause Mortality in Patients With Stage IV Colorectal Cancer Treated With Capecitabine: Single‐Center 24‐Month Observational Study in Vietnam

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