Applications of Fibrin-based products in Endodontics: A Literature Review

Bolhari, Behnam; Meraji, Naghmeh; Ghorbanzadeh, Abdollah; Sarraf, Pegah; Moayeri, Razieh Sadat

doi:10.4103/denthyp.denthyp_23_19

Cited by 5 publications

(7 citation statements)

References 2 publications

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“…It contains several factors that accelerate angiogenesis, chemotaxis, mitosis and cell proliferation [23,24]. The results of the related research indicated a beneficial antimicrobial effect of L-PRF and the release of growth factors and matrix proteins for over 7 days [24,25].…”

Section: Leucocyte Platelet-rich Fibrin (L-prf)mentioning

confidence: 99%

“…Computed tomography showed that the areas of lesions subsided or decreased and bone density increased in all teeth. Despite the rapid action of PRP, the authors drew attention to the disadvantages that are associated with this method, including the need for the taking of blood from the patient [25,52,53]. Because of this, they recommend the technique of induced bleeding as a standard procedure for the revascularization of non-vital immature permanent teeth, which gives delayed results but is less onerous [52,53].…”

Section: Regenerative Endodontic Treatment (Ret) and Blood Derivativesmentioning

confidence: 99%

“…Periodontitis is the breakdown of periodontal tissues, which occurs along with bone loss and clinical attachment, as well as apical migration of the junctional epithe-lium, which can induce the formation of vertical (angular) and/or horizontal bone defects [25,26]. It manifests in the inflammatory response of periodontal tissues to periodontal pathogens [28,57].…”

Section: Regenerative Endodontic Treatment (Ret) and Blood Derivativesmentioning

confidence: 99%

“…It manifests in the inflammatory response of periodontal tissues to periodontal pathogens [28,57]. Risk factors for this disease are poor oral hygiene, smoking, genetic predisposition and many systemic diseases, such as diabetes, cardiovascular disease and stroke [25,27].…”

Section: Regenerative Endodontic Treatment (Ret) and Blood Derivativesmentioning

confidence: 99%

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PRP and PRF—Subgroups and Divisions When Used in Dentistry

Pietruszka

Chruścicka

Duś-Ilnicka

et al. 2021

JPM

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Blood derivates, such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), are autogenous sources of many growth factors that are involved in the healing and regeneration of tissues, and for this reason, are used in dentistry treatments. This fact also contributes to the growing interest in these biomaterials in regenerative personalized medicine. The multitude of platelet-rich forms creates many possibilities for their use. This semi-systematic review describes and compares the methods of obtaining properties and potential uses of these materials in personalized treatments.

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Section: Leucocyte Platelet-rich Fibrin (L-prf)mentioning

confidence: 99%

Section: Regenerative Endodontic Treatment (Ret) and Blood Derivativesmentioning

confidence: 99%

Section: Regenerative Endodontic Treatment (Ret) and Blood Derivativesmentioning

confidence: 99%

Section: Regenerative Endodontic Treatment (Ret) and Blood Derivativesmentioning

confidence: 99%

See 2 more Smart Citations

PRP and PRF—Subgroups and Divisions When Used in Dentistry

Pietruszka

Chruścicka

Duś-Ilnicka

et al. 2021

JPM

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“…Although there is increasing development of biomaterials with natural polymers due to their similarity with ECM, the biochemical characteristics of fibrin make it suitable as a platform for autologous cell release. For a better understanding of the composition, structure, biochemical characteristics and mechanical properties of fibrin, the reader is referred to excellent reviews about this biomaterial [51][52][53]. One of the interesting features of fibrin is that it can form a three-dimensional network of elastic fibers which can promote biological interactions during the regeneration of target tissues.…”

Section: Natural Biomaterialsmentioning

confidence: 99%

A Molecular View on Biomaterials and Dental Stem Cells Interactions: Literature Review

et al. 2022

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Biomaterials and stem cells are essential components in the field of regenerative medicine. Various biomaterials have been designed that have appropriate biochemical and biophysical characteristics to mimic the microenvironment of an extracellular matrix. Dental stem cells (DT-MSCs) represent a novel source for the development of autologous therapies due to their easy availability. Although research on biomaterials and DT-MSCs has progressed, there are still challenges in the characteristics of biomaterials and the molecular mechanisms involved in regulating the behavior of DT-MSCs. In this review, the characteristics of biomaterials are summarized, and their classification according to their source, bioactivity, and different biological effects on the expansion and differentiation of DT-MSCs is summarized. Finally, advances in research on the interaction of biomaterials and the molecular components involved (mechanosensors and mechanotransduction) in DT-MSCs during their proliferation and differentiation are analyzed. Understanding the molecular dynamics of DT-MSCs and biomaterials can contribute to research in regenerative medicine and the development of autologous stem cell therapies.

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