Applications of mesoporous silica and zeolites for drug delivery

Abstract

Zeolites and mesoporous silica were used as drug delivery systems for the loading and release of small drug molecules, aspirin and 5-fluorouracil. Different parameters were varied such as aluminum content in the zeolite, effect of distribution of functional groups and the method of surface modification in case of mesoporous silica. The effect of the aforementioned variables was studied on drug loading and release from these microporous and mesoporous systems. The drug loaded materials were extensively characterized using various physical techniques such as powder X-ray diffraction, nitrogen isotherms, infrared spectroscopy, solid state NMR and thermogravimetric analysis. Quantum calculations and molecular dynamics simulations were performed in order to validate the experimental data and also to obtain a molecular level insight of the drugs inside the pores of the host materials. Drug templated synthesis of mesoporous silica was also carried out in the presence of aspirin as the template. The aspirin templated material was characterized by aforementioned techniques and showed a sustained drug release profile. vii TABLE OF CONTENTS LIST OF TABLES .

Composite Nanogels Based on Zeolite-Poly(ethylene glycol) Diacrylate for Controlled Drug Delivery

“…It is noteworthy that the maximum DTG peak for 5-FU appears at a much lower temperature in the loaded zeolite compared to the degradation temperature of the free drug molecule. This is a further indication of interactions of the zeolite framework and the drug molecule [30]. The total amount of 5-FU in the zeolite is 7.4% relative to wet zeolite and 8.3% relative to dry zeolite.…”

Encapsulation of gases in powder solid matrices and their applications: A review

“…The activation energy for diffusion of N 2 , CO 2 , and Ar in 3A zeolite was reported to be 72.38, 54.39 and 66.11 kJ mole -1 respectively [67]. In addition, release control for entrapped molecules is also obtained via surface modification by functional groups [174], and altering of zeolite-shell thickness [175].…”

Another Potentially Hazardous Zeolite from Northern Italy: Fibrous Mordenite

“…Zeolites are widely used in many fields, such as agronomy and ecology, in many industrial processes such as the production of detergents and drying agents, and in medicine [3,[28][29][30]. In particular, mordenite is a very used zeolite because of its high silica/alumina ratio, which allows it to resist exposure to high temperatures and acids, either gaseous or liquids [31,32].…”