Applications of Polyhydroxyalkanoates (PHA) in Medicine and Pharmacy

Williams, Simon F.; Martin, David P.

doi:10.1002/3527600035.bpol4004

Cited by 94 publications

(128 citation statements)

References 120 publications

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“…Thirdly, possibly the enzymatic degradation by lipase also contributed to the rapid bioabsorption of the P(3HB-co-97mol%-4HB). PHA can be enzymatically degraded by PHA depolymerases, but there is no evidence to date that these are present in vivo (Williams & Martin, 2002). P(4HB) was found to be also highly susceptible to lipase hydrolysis as opposed to P(3HB) (Mukai et al, 1993).…”

Section: Mechanism Of Bioabsorption Of Nanofibrous Scaffolds (A) Pha mentioning

confidence: 99%

Nanofibrous Scaffolds of Bio-Polyesters: In Vitro and In Vivo Characterizations and Tissue Response

Tang¹,

Ishii²,

Sudesh³

et al. 2010

Nanofibers

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Section: Mechanism Of Bioabsorption Of Nanofibrous Scaffolds (A) Pha mentioning

confidence: 99%

Nanofibrous Scaffolds of Bio-Polyesters: In Vitro and In Vivo Characterizations and Tissue Response

Tang¹,

Ishii²,

Sudesh³

et al. 2010

Nanofibers

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“…It has been reported that in some PHAs, including 3-and 4-polyhydroxybutyrate, in vivo resorption involves active participation of phagocytic macrophages and foreign body giant cells (FBGCs) (Williams and Martin, 2002). In our recent study we investigated tissue response to polyhydroxybutyrate monofilament sutures used to close muscle-fascial wounds and found out that macrophages played an important role in the tissue repair response, phagocytizing injured cells and tissues and polymer particles and degradation products (Shishatskaya et al, 2004a).…”

Section: In Vivo Reactionmentioning

confidence: 99%

“…However, those investigations were performed using large implants, in the form of sutures, film grafts or pins (Williams and Martin, 2002;Qu et al, 2006). It is well-known, though, that biocompatibility of biomaterials depends not only on the chemical structure and purity of the specimens but, to a large extent, on the size and shape of the implant (Anderson and Shive, 1997).…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility of polyhydroxybutyrate microspheres: in vitro and in vivo evaluation

Shishatskaya

Voinova

Goreva

et al. 2008

J Mater Sci: Mater Med

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Microspheres have been prepared from the resorbable linear polyester of β-hydroxybutyric acid (polyhydroxybutyrate, PHB) by the solvent evaporation technique and investigated in vitro and in vivo. Biocompatibility of the microspheres has been proved in tests in the culture of mouse fibroblast cell line NIH 3Т3 and in experiments on intramuscular implantation of the microspheres to Wistar rats for 3 months. Tissue response to the implantation of polymeric microspheres has been found to consist in a mild inflammatory reaction, pronounced macrophage infiltration that increases over time, involving mono-and poly-nuclear foreign body giant cells that resorb the polymeric matrix. No fibrous capsules

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“…The biocompatibity of PHAs is also suspect. Subcutaneous poly(3-hydroxybutyrate) implants lead to a variety of inflammatory reactions 47 . Macrophages, neutrophils, lymphocytes, and fibrocytes were all found immediately surrounding the implant.…”

Section: Existing Biodegradable Elastomersmentioning

confidence: 99%

Biodegradable Microfluidic Scaffolds for Vascular Tissue Engineering

2004

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This work describes the integration of novel microfabrication techniques for vascular tissue engineering applications in the context of a novel biodegradable elastomer. The field of tissue engineering and organ regeneration has been born out of the high demand for organ transplants. However, one of the critical limitations in regeneration of vital organs is the lack of an intrinsic blood supply. This work expands on the development of microfluidic scaffolds for vascular tissue engineering applications by employing microfabrication techniques. Unlike previous efforts, this work focuses on fabricating this scaffolds from poly(glycerol-sebacate) (PGS), a novel biodegradable elastomer with superior mechanical properties. The transport properties of oxygen and carbon dioxide in PGS were measured through a series of time-lag diffusion experiments. The results of these measurements were used to calculate a characteristic length scale for oxygen diffusion limits in PGS scaffolds. Microfluidic scaffolds were then produced using fabrication techniques specific for PGS. Initial efforts have resulted in solid PGS-based scaffolds with biomimetic fluid flow and capillary channels on the order of 10 microns in width. These scaffolds have also been seeded with endothelial cells and perfused continuously in culture for up to 14 days resulting in partially confluent channels. More complex fabrication techniques were also demonstrated. A novel electrodeposition technique was used in the fabrication of biomimetic :tnicrofluidic masters. Thin-walled devices were also synthesized to accommodate the relatively low gas permeability of PGS.

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Applications of Polyhydroxyalkanoates (PHA) in Medicine and Pharmacy

Abstract: Introduction Historical Outline PHA Preparation and Properties: A Primer Production Mechanical and Thermal Properties Sterilization of PHA Polymers Biocompatibility Natural Occurrence In vitro … Show more

Cited by 94 publications

References 120 publications

Nanofibrous Scaffolds of Bio-Polyesters: In Vitro and In Vivo Characterizations and Tissue Response

Nanofibrous Scaffolds of Bio-Polyesters: In Vitro and In Vivo Characterizations and Tissue Response

Biocompatibility of polyhydroxybutyrate microspheres: in vitro and in vivo evaluation

Biodegradable Microfluidic Scaffolds for Vascular Tissue Engineering

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