Applications to Biosensors

Kano, Kenji; Shirai, Osamu; Kitazumi, Yuki; Sakai, Kyosuke; Xia, Hong-qi

doi:10.1007/978-981-15-8960-7_6

Cited by 3 publications

(3 citation statements)

References 33 publications

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“…Level Reference Electrochemical method based on DNA probe fM [34], [38], [39], [41], [42] Electrochemical method based on antigen antibody fM [51], [52] Fluorescence method pM [57],[58] Amplified colorimetric method pM [59]…”

Section: Methodsmentioning

confidence: 99%

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Electroanalytical Biosensors for Circulating Tumor DNA Detection—A Brief Review

Peng¹,

Lin²,

Nian³

et al. 2021

Preprint

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Early diagnosis and treatment have always been highly desired in the fight against cancer, and detection of circulating tumor DNA (ctDNA) has recently been touted as highly promising for early cancer screening. Consequently, the detection of ctDNA in liquid biopsy gains much attention in the field of tumor diagnosis and treatment, which has also attracted research interest from the industry. However, traditional gene detection technology is difficult to achieve low cost, real-time and portable measurement of ctDNA. Electroanalytical biosensors have many unique advantages such as high sensitivity, high specificity, low cost and good portability. Therefore, this review aims to discuss the latest development of biosensors for minimal-invasive, rapid, and real-time ctDNA detection. Various ctDNA sensors are reviewed with respect to their choices of receptor probes, detection strategies and figures of merit. Aiming at the portable, real-time and non-destructive characteristics of biosensors, we analyze their development in the Internet of Things, point-of-care testing, big data and big health.

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Section: Methodsmentioning

confidence: 99%

“…Antibody have been widely used in disease diagnosis and treatment, food safety control and environmental monitoring [42] . Specific binding by antibody is the foundation for the detection of pathogens, micro molecules, cells, bacteria, and other molecules with biological characteristics.…”

Section: Antibody Probe-based Detectionmentioning

confidence: 99%

Electroanalytical Biosensors for Circulating Tumor DNA Detection—A Brief Review

Peng¹,

Lin²,

Nian³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Antibodies have been widely used in disease diagnosis and treatment, food safety control, and environmental monitoring [ 49 ]. Specific binding by an antibody is the foundation for the detection of pathogens, micro-molecules, cells, bacteria, and other molecules with biological characteristics.…”

Section: Antibody Probe-based Detectionmentioning

confidence: 99%

Electrochemical Biosensors for Circulating Tumor DNA Detection

et al. 2022

View full text Add to dashboard Cite

Early diagnosis and treatment have always been highly desired in the fight against cancer, and detection of circulating tumor DNA (ctDNA) has recently been touted as highly promising for early cancer-screening. Consequently, the detection of ctDNA in liquid biopsy is gaining much attention in the field of tumor diagnosis and treatment, which has also attracted research interest from industry. However, it is difficult to achieve low-cost, real-time, and portable measurement of ctDNA in traditional gene-detection technology. Electrochemical biosensors have become a highly promising solution to ctDNA detection due to their unique advantages such as high sensitivity, high specificity, low cost, and good portability. Therefore, this review aims to discuss the latest developments in biosensors for minimally invasive, rapid, and real-time ctDNA detection. Various ctDNA sensors are reviewed with respect to their choices of receptor probes, designs of electrodes, detection strategies, preparation of samples, and figures of merit, sorted by type of electrode surface recognition elements. The development of biosensors for the Internet of Things, point-of-care testing, big data, and big health is analyzed, with a focus on their portable, real-time, and non-destructive characteristics.

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Emerging ctDNA detection strategies in clinical cancer theranostics

Yi,

Wang,

Filippov

et al. 2023

Smart Medicine

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Circulating tumor DNA (ctDNA) is naked DNA molecules shed from the tumor cells into the peripheral blood circulation. They contain tumor‐specific gene mutations and other valuable information. ctDNA is considered to be one of the most significant analytes in liquid biopsies. Over the past decades, numerous researchers have developed various detection strategies to perform quantitative or qualitative ctDNA analysis, including PCR‐based detection and sequencing‐based detection. More and more studies have illustrated the great value of ctDNA as a biomarker in the diagnosis, prognosis and heterogeneity of tumor. In this review, we first outlined the development of digital PCR (dPCR)‐based and next generation sequencing (NGS)‐based ctDNA detection systems. Besides, we presented the introduction of the emerging ctDNA analysis strategies based on various biosensors, such as electrochemical biosensors, fluorescent biosensors, surface plasmon resonance and Raman spectroscopy, as well as their applications in the field of biomedicine. Finally, we summarized the essentials of the preceding discussions, and the existing challenges and prospects for the future are also involved.

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Applications to Biosensors

Cited by 3 publications

References 33 publications

Electroanalytical Biosensors for Circulating Tumor DNA Detection—A Brief Review

Electroanalytical Biosensors for Circulating Tumor DNA Detection—A Brief Review

Electrochemical Biosensors for Circulating Tumor DNA Detection

Emerging ctDNA detection strategies in clinical cancer theranostics

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