Applying a diffusion of innovations framework to the scale-up of direct-acting antiviral therapies for hepatitis C virus infection: Identified challenges for widespread implementation

Marshall, Alison D.; Hopwood, Max; Grebely, Jason; Treloar, Carla

doi:10.1016/j.drugpo.2020.102964

Cited by 7 publications

(2 citation statements)

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“…Marshall et al (2020) leveraged the DOI framework to identify the most salient structural factors that could facilitate or inhibit the widespread promotion and adoption of direct-acting anti-viral therapies for hepatitis C virus. The researchers similarly recognized that individuals with specialized occupational expertise comprised the most innovative and in uential adopter and diffuser (i.e., promoter) of an innovation, nding that drug and alcohol specialists -rather than general practitioners -were most likely to aid the scaling up of anti-viral treatments (Marshall et al, 2020). In the malaria context, Steury (2013) utilized the DOI to develop an applied model to implement communityfocused malaria treatment invertions in Zambia.…”

Section: Expand Availabilitymentioning

confidence: 99%

Evaluating the Implementation and Adoption Potential of a Saliva-based Malaria Detection Technique in the Democratic Republic of the Congo

Diaz

Gusto

McCoy

et al. 2022

Preprint

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Background: The reliance on blood for thin and thick blood smear microscopy – using a relatively invasive procedure – has precluded the use of reliable diagnostic tests in non-clinical settings at the Point-of-Need (PON). To improve the capacity of non-blood-based rapid diagnostic tests to confirm subclinical infections and thereby identify and quantify the human reservoir at the PON, a cross-sectoral collaboration between university researchers and commercial partners produced an innovative, non-invasive saliva-based RDT capable of identifying novel, non-hrp2/3 parasite biomarkers. While this new Saliva-based Malaria Asymptomatic and Asexual Rapid Test (SMAART-1) shows increased detection sensitivity and precision potential by identifying a new P. falciparum protein marker (PSSP17), appraising its utility in the field – particularly with respect to its adoption potential with children and adults in high risk, endemic regions – is necessary to warrant its continued development.Methods: The purpose of this study was to evaluate the acceptability, usability, and adoption potential of the SMAART-1 at select PON sites in the Kinshasa Province. Teachers, community health workers, nurses, and laboratory technicians participated in data collection at three distinct community sites in Kinshasa Province, Democratic Republic of the Congo. Three data collection methods were utilized in this mixed methods study to provide an overarching performance and usability evaluation of the SMAART-1 at PON field sites: observation checklists of SMAART-1 implementation, focus group discussions, and surveys with local health care practitioners – particularly teachers and community health workers.Results: Findings indicate participants were interested in and supportive of the SMAART-1 protocol, with approximately 99% of the participants surveyed indicating that they either “agreed” or “strongly agreed” with the statement that they “would use the saliva-based malaria asymptomatic rapid test as part of a community malaria detection and treatment program.” Data also suggest that the protocol was broadly appealing for its testing sensitivity and ease of use.Conclusions: The SMAART-1 protocol’s clinically reliable results demonstrate a promising new level of sensitivity and precision for detecting parasite biomarkers. This study’s evaluation of the protocol’s utility and adoption potential in the field, with a target user audience, advances its development and points to opportunities to expand evaluation efforts.

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Section: Expand Availabilitymentioning

confidence: 99%

Evaluating the Implementation and Adoption Potential of a Saliva-based Malaria Detection Technique in the Democratic Republic of the Congo

Diaz

Gusto

McCoy

et al. 2022

Preprint

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“…This dissertation is a combination of three empirical papers that use this framework in three different case studies and across different fields: social movements, organizations, and health. Diffusion has established itself as a solid multidisciplinary theory over the years that is often used in sociology , economics (Adelowotan and Udofia 2021; Outcault, Sanguinetti, and Nelson 2022), public health (Green et al 2009;Marshall et al 2020), or communication (Johann and Bülow 2019;Kim 2015). Hence, this project seeks to demonstrate the versatility of the theory to explain social change.…”

Section: Introductionmentioning

confidence: 99%

Untangling processes in the diffusion of innovative practices: slutWalks, gender equity strategies, and Covid 19 vaccines

Falguieres

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Technologies, health treatments, ideas or behaviors can all be innovative practices that bring societal changes if they are largely adopted by individuals, states, or organizations.Grounded in the theory of the diffusion of innovation, this dissertation aims at uncovering some of the factors explaining the diffusion of three innovative practices: the feminist rallies named SlutWalks, gender equity strategies for the STEM academia workforce and the Covid-19 vaccines. The first paper addresses how the historical capacity for activism and social media served as vectors of diffusion for feminist rallies, SlutWalks, in 293 US cities between 2011 and 2014. Using event history analysis and logistic models, I find that cities with a Student for Democratic Society chapter in the 1960s were more likely to have a SlutWalk. I argue that cities imitate each other because they share a cultural identity based on a similar historical capacity for activism. The second paper investigates the role of social status and homophily in the collaboration and diffusion of gender equity practices among ADVANCE awarded universities.ADVANCE is an NSF program that awards universities to create and apply gender equity practices in the STEM workforce. Using 97 abstracts from the awarded proposals, I built up two networks: 1) collaborative ties between 205 universities and 2) ties based on imitation of practices between 65 universities. I demonstrate via network analysis that universities with a higher Carnegie classification hold a central position in the network and are more likely to be innovators and imitated by other universities. Collaborative universities are also highly homophile along status lines, and less so based on geography. I argue that while high status organizations remain highly influential for future diffusion of practices, the ADVANCE program has fostered increasing participation and collaboration from lower status universities such as colleges and minority serving institutions. rigorous feedback and advice at the early and final stages of this dissertation. I am also grateful to Laura Nelson and Kathrin Zippel for helping me define the dissertation topic by incorporating me into their projects. Laura Nelson helped me build up my first paper, let me use her data on SlutWalk and social media and provided me with strong feedback and recommendations on the project. Kathrin Zippel allowed me as well to use data from her NSF ADVANCE project and gave me guidance based on her strong expertise on the subject. I also would like to extend my thanks to the Sociology Department at Northeastern in general and to my graduate cohort who made my early days in the program more enjoyable. Particularly, many thanks to Pam Simmons for her warm encouragement. This work would not have been possible without the love and support from my family and friends. Thank you to my dear friend Sarah Detzner who helped me with the editing and proofreading of the text and for her constant support. Thank you for all my friends from the United States and France w...

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“It's time!”: A qualitative exploration of the acceptability of hepatitis C notification systems to help eliminate hepatitis C

Walker

Wallace

Latham

et al. 2021

International Journal of Drug Policy

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Applying a diffusion of innovations framework to the scale-up of direct-acting antiviral therapies for hepatitis C virus infection: Identified challenges for widespread implementation

Cited by 7 publications

References 51 publications

Evaluating the Implementation and Adoption Potential of a Saliva-based Malaria Detection Technique in the Democratic Republic of the Congo

Evaluating the Implementation and Adoption Potential of a Saliva-based Malaria Detection Technique in the Democratic Republic of the Congo

Untangling processes in the diffusion of innovative practices: slutWalks, gender equity strategies, and Covid 19 vaccines

“It's time!”: A qualitative exploration of the acceptability of hepatitis C notification systems to help eliminate hepatitis C

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