Apport de la biopsie d’endomètre dans l’évaluation de la réceptivité utérine

Comparative multiplex analysis of cytokines, chemokines and growth factors in follicular fluid of normoresponder women undergoing ovum donation with gonadotropin-releasing hormone agonist versus gonadotropin-releasing hormone antagonist protocols

“…On the other hand, pregnancy outcome on embryo transfer, which although provides direct proof of concept, depends on multifactorial processes acting in a non-linear combinatorial manner, which involve embryonic growth and endometrial ecology of the recipients as well. [5455] Furthermore, the concept of identifying molecular predictors of oocyte evaluation is an important one because substantial evidence suggests that oocyte quality significantly affects fertilization and subsequent embryo development and that morphological predictors are often misleading. [56] The present study provides the proof of this concept and it appears that molecular examination of follicular fluid along with morphological and cellular characteristics may eventually identify significant biomarkers in follicular fluid having more precise and objective predictor value in near future.…”

Potential Pathophysiological Mechanisms of the Beneficial Role of Endometrial Injury in In Vitro Fertilization Outcome

“…2 –5 During controlled ovarian hysperstimulation (COH) for either intrauterine insemination or IVF, the regular course of endometrial periodicity is altered in the context of the noted delayed tissue proliferation and endometrial development, as compared with natural cycles, through the alterations in messenger RNA levels of progesterone receptors 6 or premature secretory changes in the postovulatory and early luteal phases. 7 Moreover, markers of endometrial receptivity, such as leukemia inhibitory factor (LIF) and integrin b3, are reduced during COH, when compared to natural cycles, and this phenomenon is clearly more marked in “high response cycles.” 8…”