Apport du protidogramme sérique dans la sélection de donneurs de sang à Abidjan

Yayo, S.E.D.; Hauhouot-Attoungbre, M.-L.; Houphouet, Felix; Ake-Edjeme, A.; Ahibo, H.; Diafouka, F.; Monnet, Dominique

doi:10.1016/j.immbio.2008.10.008

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…Elle s'est déroulée de septembre à décembre 2016 sur des PV-VIH naïfs de tout traitement ARV, pris en charge au centre médical de suivi des donneurs de sang (CMSDS) et des sujets présumés sains, donneurs volontaires de sang (Yayo et al, 2009). Tous présentaient une concentration anormale d'au moins l'un des paramètres lipoprotéiques sanguins suivants : TG, CT, C-HDL, C-LDL, Apo A1, ApoB100.…”

Section: Materiel Et Methodes Type D'étudeunclassified

Mutations du gène d’apoprotéine B100 au cours des dyslipidémies chez les sujets vivant avec le VIH

Kone¹,

Toni²,

Edjeme-Ake³

et al. 2018

Int. J. Bio. Chem. Sci

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Apoprotein B100 gene mutations and dyslipidemia in HIV-infected patients ABSTRACT Apolipoproteins constitute part of the lipoproteins complex. They are responsible for their metabolism and transportation. The aim of this study was to investigate the Apolipoprotein B100 gene's exons 26 and 29 mutations in PLHIV having dyslipidemia. This descriptive cross-sectional study included 16 dyslipidemic subjects (5 healthy and 11 HIV-positive). The mutations were investigated by DNA sequencing. Dual nucleotide populations were frequent at mutation points (exon 26: 81.2% and exon 29: 100%). Misense mutations were predominant (exon 26: 94.1% and exon 29: 85.7%) and they were often substitutions of cytosine at position 3329 (47.1%, n = 8/17) and guanine at 454 (71.4%; n=5/7) in exons 26 and 29 respectively.F. KONE et al. / Int.

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Section: Materiel Et Methodes Type D'étudeunclassified

Mutations du gène d’apoprotéine B100 au cours des dyslipidémies chez les sujets vivant avec le VIH

Kone¹,

Toni²,

Edjeme-Ake³

et al. 2018

Int. J. Bio. Chem. Sci

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Monoclonal Gammopathies of Undetermined Significance and Abnormal Serum Protein Rates Prevelance in Blood Donors: For Improved Transfusion Safety

Benzouarhia,

Anibat,

El Maliki

et al. 2024

Global Journal of Transfusion Medicine

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Background and Objectives: Protein abnormalities include monoclonal gammopathies of undetermined significance (MGUS) and malignant lymphoplasmacytic tumors such as multiple myeloma (MM), Waldenström macroglobulinemia, and amyloid light-chain amyloidosis. MGUS prevalence increases with age, especially in individuals over 50. MGUS progresses to various lymphoplasmacytic diseases, including smoldering MM and MM. Almost all blood donors (BDs) are asymptomatic but some of them could present protein abnormalities. Our objective was to assess the prevalence and impact of protein abnormalities and monoclonal gammopathies (MGs) on transfusion safety among BDs in Morocco. Methods: Two hundred eighty-one serum samples were collected from BDs aged over 40 years old. Total serum protein measurement and protein electrophoresis were performed using the Architect ci8200 and Capillarys-2-Piercing automated systems, respectively. Immunofixation was conducted using hydrates. Results: Protein levels ranged between 59 and 87 g/L (average = 71.69 ± 4.96 g/L). Our results showed 195 (69.39%) normal profiles, 6 (2.13%) MGs, 14 (4.98%) heterogeneous restriction of γ-globulins, and 66 other abnormalities (23.48%) regarding the levels of albumin and proteins from alpha and beta fractions. Conclusion: Our preliminary results appeal to blood transfusion professionals regarding ethical considerations and transfusion safety. BDs with abnormal protein levels should benefit systematically from diagnostic tests and therapies.

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Apport du protidogramme sérique dans la sélection de donneurs de sang à Abidjan

Cited by 2 publications

References 7 publications

Mutations du gène d’apoprotéine B100 au cours des dyslipidémies chez les sujets vivant avec le VIH

Mutations du gène d’apoprotéine B100 au cours des dyslipidémies chez les sujets vivant avec le VIH

Monoclonal Gammopathies of Undetermined Significance and Abnormal Serum Protein Rates Prevelance in Blood Donors: For Improved Transfusion Safety

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