Appraising the Real-Life Need for Extracorporeal Membrane Oxygenation during the COVID-19 Pandemic

Chambrun, Pineton de; Brodie, Daniel

doi:10.1164/rccm.202104-0897ed

Cited by 3 publications

(1 citation statement)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All patients were discharged from the hospital approximately 20 days after admission. Three out of nine patients in a matched control group died and CRP decrease was delayed [ 79 ].…”

Section: Augmentation Therapy For Patients With Covid-19mentioning

confidence: 99%

Correlation between α1-Antitrypsin Deficiency and SARS-CoV-2 Infection: Epidemiological Data and Pathogenetic Hypotheses

Vianello

Guarnieri

Braccioni

et al. 2021

JCM

View full text Add to dashboard Cite

The most common hereditary disorder in adults, α1-antitrypsin deficiency (AATD), is characterized by reduced plasma levels or the abnormal functioning of α1-antitrypsin (AAT), a major human blood serine protease inhibitor, which is encoded by the SERine Protein INhibitor-A1 (SERPINA1) gene and produced in the liver. Recently, it has been hypothesized that the geographic differences in COVID-19 infection and fatality rates may be partially explained by ethnic differences in SERPINA1 allele frequencies. In our review, we examined epidemiological data on the correlation between the distribution of AATD, SARS-CoV-2 infection, and COVID-19 mortality rates. Moreover, we described shared pathogenetic pathways that may provide a theoretical basis for our epidemiological findings. We also considered the potential use of AAT augmentation therapy in patients with COVID-19.

show abstract

“…All patients were discharged from the hospital approximately 20 days after admission. Three out of nine patients in a matched control group died and CRP decrease was delayed [ 79 ].…”

Section: Augmentation Therapy For Patients With Covid-19mentioning

confidence: 99%