The article investigates the theoretical aspects, features and the main directions of development of human security concept. On the basis of systematization of scientific sources; and summarizing the experience of scientists, whose works are devoted to the problems of analysis and assessment the level of human security, the author improved the system of indicators that underlies the classification regions of Ukraine. According to the results of cluster analysis, the regions are grouped into six clusters. The article analyzes the dynamics of quantitative distribution regions of Ukraine according to the selected clusters. In the research process, we defined the cores with a constant composition of regions and presented the characteristics of each cluster. It is interesting to note that the appearance of the last (sixth) cluster has been observed since 2014, according to a number of objective reasons. The results of the study indicate a rather pronounced unevenness in the state of human security in the regions of Ukraine.