Approaches to enhancing the sensitivity of capillary electrophoresis methods for the determination of inorganic and small organic anions

Abstract

One of the major problems facing the development of capillary electrophoresis (CE) is the relatively high limits of detection when compared to traditional high-performance liquid chromatographic (HPLC) methods. While the use of an alternative detector can offer better sensitivity, a more universal approach is sample preconcentration. Numerous on-line methods have been developed to improve the sensitivity of CE, and are based on electrophoretic principles, chromatographic principles, or a combination of both. This review will discuss all forms of on-line preconcentration methods for CE, with emphasis given to those that have shown particular merit when applied to inorganic and small organic anions.

Application of pH-sensitive magnetic nanoparticles microgel as a sorbent for the preconcentration of phenoxy acid herbicides in water samples

“…A c c e p t e d M a n u s c r i p t 5 has limited the use of it as an effective method for trace analysis in environmental samples [25].…”

The importance of capillary electrophoresis, capillary electrochromatography, and ion chromatography in separations of inorganic ions

“…On the other hand, extremely small flowrates in CE are usually advantageous for postcolumn MS detection. (Methods for enhancing the CE sensitivity were recently reviewed [6]). …”

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