Approaches to Regenerate Hair Cell and Spiral Ganglion Neuron in the Inner Ear

Waqas, Muhammad; Chai, Renjie

doi:10.1007/978-3-030-40413-0_4

Cited by 2 publications

(1 citation statement)

References 145 publications

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“…Therefore, it is possible, that in future studies also stem cell derived neurons could be applied. This would limit batch to batch variety of cell isolation and also allow autologous transplantation in later clinical settings [12]. Thus, innovative technologies based on "biohybrid" systems utilizing the functional interaction between biological (eg, neural) systems and artificial devices could emerge for improved treatment of neurological and sensorineural disorders such as hearing loss.…”

Section: Discussionmentioning

confidence: 99%

Probing interneuronal cell communication via optogenetic stimulation

Heeger

Harre

Warnecke

et al. 2021

Transl Biophotonics

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This study uses an all‐optical approach to probe interneuronal communication between spiral ganglion neurons (SGNs) and neurons of other functional units, in this case cortex neurons (CNs) and hippocampus neurons (HNs), for the first time. We combined a channelrhodopsin variant (CheRiff) with a red genetically encoded calcium indicator (jRCaMP1a), enabling simultaneous optical stimulation and recording from spatially separated small neuronal populations. Stimulation of SGNs was possible with both optogenetic manipulated HNs and CNs, respectively. Furthermore, a dependency on the pulse duration of the stimulating light in regard to the evoked calcium response in the SGNs was also observed. Our results pave the way to enable innovative technologies based on “biohybrid” systems utilizing the functional interaction between different biological (eg, neural) systems. This can enable improved treatment of neurological and sensorineural disorders such as hearing loss.

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Section: Discussionmentioning

confidence: 99%