Approaches Towards Better Immunosuppressive Agents
Juliusz Walczak,
Dorota Iwaszkiewicz-Grześ,
Grzegorz Cholewiński
Abstract:Several classes of compounds are applied in clinics due to their immunosuppressive properties in transplantology and the treatment of autoimmune diseases. Derivatives of mycophe-nolic acid, corticosteroids and chemotherapeutics bearing heterocyclic moieties like methotrexate, azathioprine, mizoribine, and ruxolitinib are active substances with investigated mechanisms of action. However, improved synthetic approaches of known drugs and novel derivatives are still being reported to attempt better accessibility a… Show more
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