2003
DOI: 10.1002/j.1551-8833.2003.tb10393.x
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Approaching DBP toxicity as a mixtures problem

Abstract: Positive epidemiologic and toxicologic studies underline the need for assessment of human health risks from ubiquitous exposures to mixtures of disinfection by-products (DBPs). Typical human exposures to DBPs are at extremely low levels; thus, health risk is likely to be attributable to multiple, rather than single, DBP exposures. This article suggests three approaches to evaluating health risks from DBP mixtures: (1) toxicologic studies of simple defined mixtures,(2) toxicologic studies using reproducible dis… Show more

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Cited by 28 publications
(7 citation statements)
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“…For example, about 11 percent of the samples contained chloroform and bromodichloromethane, both of which are DBPs (table 22). Several recent studies have begun to evaluate DBP mixtures in drinking water because of widespread exposures to these complex mixtures and because epidemiologic and toxicologic studies of DBPs have raised concerns for human health (Teuschler and Simmons, 2003;U.S. Environmental Protection Agency, 2003b;Simmons and others, 2004;Teuschler and others, 2004).…”
Section: Composition Of Mixturesmentioning
confidence: 99%
“…For example, about 11 percent of the samples contained chloroform and bromodichloromethane, both of which are DBPs (table 22). Several recent studies have begun to evaluate DBP mixtures in drinking water because of widespread exposures to these complex mixtures and because epidemiologic and toxicologic studies of DBPs have raised concerns for human health (Teuschler and Simmons, 2003;U.S. Environmental Protection Agency, 2003b;Simmons and others, 2004;Teuschler and others, 2004).…”
Section: Composition Of Mixturesmentioning
confidence: 99%
“…This finding was observed regardless of the complexity of (number of contaminants detected in) the mixtures (Hopple and others, 2009). Several recent studies have begun to evaluate DBP mixtures in drinking water because of widespread exposures to these complex mixtures and because epidemiologic and toxicologic studies of DBPs have raised concerns for human health (Teuschler and Simmons, 2003;U.S. Environmental Protection Agency, 2003b;Simmons and others, 2004;Teuschler and others, 2004).…”
Section: Composition Of Mixturesmentioning
confidence: 99%
“…The quality of drinking water in Taiwan has been the subject of many consumer complaints because of its chlorination disinfection by-products (CDBPs). Notably, CDBPs are considered to be risk factors for animal mutagenicity or carcinogenicity and to represent potential human health risks (Lin and Hoang 2000;Teuschler and Simmons 2003;Tokmak et al 2004). Earlier studies (Arora et al 1997) have proposed that trihalomethanes (THMs) and haloacetic acids (HAA 5 ) are two predominant disinfection byproducts (DBPs) in drinking water, along fluvic acid.…”
Section: Introductionmentioning
confidence: 98%