Approaching Two Decades: Biomolecular Coronas and Bio–Nano Interactions

Abstract

It has been nearly two decades since the term "protein corona" was coined. This term has since evolved to "biomolecular corona" or "biocorona" to capture the diverse biomolecules that spontaneously form on the surface of nanoparticles upon exposure to biological fluids and drive nanoparticle interactions with biological systems. In this Perspective, we highlight the significant progress in this field, including studies on nonprotein corona components, lipid nanoparticles, and the role of the corona in endogenous organ targeting. We also discuss research opportunities in this field, particularly the need for improved characterization and standardization of analysis and how recent advances in artificial intelligence and ex vivo models can improve our understanding of the biomolecular corona in guiding nanomedicine design.