Appropriate <i>Bmp7</i> levels are required for the differentiation of midline guidepost cells involved in corpus callosum formation

Sánchez-Camacho, Cristina; Ortega, Joaquı́n M.; Ocaña, Inmaculada; Alcántara, Soledad; Bovolenta, Paola

doi:10.1002/dneu.20865

Cited by 18 publications

(11 citation statements)

References 73 publications

(85 reference statements)

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“…Contribution of the TGF signaling to the differentiation of the midline glia was also reported in the recent literature [125]. Sánchez-Camacho and collaborators observed an expression of BMP7 in the presumptive tissue of the midline glia and found that the genetic loss of BMP7 in mice results in profound alterations of the glial wedge and the indusium griseum glia.…”

Section: Role Of Guidepost Cells In the Formation Of The Corpussupporting

confidence: 55%

Building Spinal and Brain Commissures: Axon Guidance at the Midline

Castellani

2013

ISRN Cell Biology

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Commissural circuits are brain and spinal cord connections which interconnect the two sides of the central nervous system (CNS). They play essential roles in brain and spinal cord processing, ensuring left-right coordination and synchronization of information and commands. During the formation of neuronal circuits, all commissural neurons of the central nervous system must accomplish a common task, which is to project their axon onto the other side of the nervous system, across the midline that delineates the two halves of the CNS. How this task is accomplished has been the topic of extensive studies over the last past 20 years and remains one of the best models to investigate axon guidance mechanisms. In the first part of this review, I will introduce the commissural circuits, their general role in the physiology of the nervous system, and their recognized or suspected pathogenic properties in human diseases. In the second part of the review, I will concentrate on two commissural circuits, the spinal commissures and the corpus callosum, to detail the cellular and molecular mechanisms governing their formation, mostly during their navigation at the midline.

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Section: Role Of Guidepost Cells In the Formation Of The Corpussupporting

confidence: 55%

Building Spinal and Brain Commissures: Axon Guidance at the Midline

Castellani

2013

ISRN Cell Biology

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“…Various mutant mice that lack proteins involved in either axon guidance and/or midline guidepost cell development have been previously identified with callosal agenesis (Bagri et al, 2002; Fothergill et al, 2014; Islam et al, 2009; Keeble et al, 2006; Magnani et al, 2014; Mendes et al, 2006; Niquille et al, 2009; Piper et al, 2009b; Sanchez-Camacho et al, 2011; Smith et al, 2006). The prevailing hypothesis from these studies has therefore been that congenital callosal agenesis predominantly results from defects in axon guidance mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Astroglial-Mediated Remodeling of the Interhemispheric Midline Is Required for the Formation of the Corpus Callosum

et al. 2016

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The corpus callosum is the major axon tract that connects and integrates neural activity between the two cerebral hemispheres. Although ∼1:4000 children are born with developmental absence of the corpus callosum, the primary etiology of this condition remains unknown. Here, we demonstrate that midline crossing of callosal axons is dependent upon the prior remodeling and degradation of the intervening interhemispheric fissure. This remodeling event is initiated by astroglia either side of the interhemispheric fissure, which intercalate with one another and degrade the intervening leptomeninges. Callosal axons then preferentially extend over these specialized astroglial cells to cross the midline. A key regulatory step in interhemispheric remodeling is the differentiation of these astroglia from radial glia, which is initiated by Fgf8 signaling to downstream Nfi transcription factors. Crucially, our findings from human neuroimaging studies reveal that developmental defects in interhemispheric remodeling are likely to be a primary etiology underlying human callosal agenesis.

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“…Midline crossing of callosal axons is controlled by several glial and neuronal guideposts specifically located along the callosal path. BMP-7 has been shown to be required at different steps of organization and differentiation of these guidepost cells, which allows formation of the corpus callosum (Sanchez-Camacho et al, 2011). Additional evidence also indicates that BMP-7, secreted from the meninges, is involved in a morphogenic cascade, including Wnt3a and GDF-5, allowing correct corpus callosum development and prevents premature axon projection (Choe et al, 2012).…”

Section: Bmps In Nervous System Development and Maintenancementioning

confidence: 99%

BMP signaling in telencephalic neural cell specification and maturation

Gámez¹,

Rodríguez-Carballo²,

Ventura³

2013

Front. Cell. Neurosci.

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Bone morphogenetic proteins (BMPs) make up a family of morphogens that are critical for patterning, development, and function of the central and peripheral nervous system. Their effects on neural cells are pleiotropic and highly dynamic depending on the stage of development and the local niche. Neural cells display a broad expression profile of BMP ligands, receptors, and transducer molecules. Moreover, interactions of BMP signaling with other incoming morphogens and signaling pathways are crucial for most of these processes. The key role of BMP signaling suggests that it includes many regulatory mechanisms that restrict BMP activity both temporally and spatially. BMPs affect neural cell fate specification in a dynamic fashion. Initially they inhibit proliferation of neural precursors and promote the first steps in neuronal differentiation. Later on, BMP signaling effects switch from neuronal induction to promotion of astroglial identity and inhibition of neuronal or oligodendroglial lineage commitment. Furthermore, in postmitotic cells, BMPs regulate cell survival and death, to modulate neuronal subtype specification, promote dendritic and axonal growth and induce synapse formation and stabilization. In this review, we examine the canonical and non-canonical mechanisms of BMP signal transduction. Moreover, we focus on the specific role of BMPs in the nervous system including their ability to regulate neural stem cell proliferation, self-renewal, lineage specification, and neuronal function.

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Appropriate Bmp7 levels are required for the differentiation of midline guidepost cells involved in corpus callosum formation

Cited by 18 publications

References 73 publications

Building Spinal and Brain Commissures: Axon Guidance at the Midline

Building Spinal and Brain Commissures: Axon Guidance at the Midline

Astroglial-Mediated Remodeling of the Interhemispheric Midline Is Required for the Formation of the Corpus Callosum

BMP signaling in telencephalic neural cell specification and maturation

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