APRIL levels strongly correlate with IL-17 in systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that may involve several organs. The disease is characterized by a recurring pattern of remission and flare. Immunologic factors seem to have important roles in the pathogenesis of SLE. Several studies revealed that cytokines are important in pathogenesis of this disorder. These cytokines include B-cell activating factor (BAFF), tumor necrosis factor (TNF), interferon (IFN), interleukin (IL)-23, IL-17, IL-10, IL-6 and IL-21. In this article, the role of cytokines and their encoding genes are described and therapeutic applications have been discussed briefly.

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“…It has been accompanied by an increase of IL-17 and IFN-γ. This association may be due to the role of Th17 helper in activation of SLE (39,40).…”

Section: Cytokine Cascade In Systemic Lupus Erythematosusmentioning

confidence: 99%

Cytokines in systemic lupus erythematosus: their role in pathogenesis of disease and possible therapeutic opportunities

et al. 2017

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“…To determine the clinical significance of serum BAFF levels measured before and after transplantation, we chose to observe the correlation of BAFF levels with clinical parameters, and then to divide each group of patients into tertiles according to serum BAFF levels as there has been no reference range yet that has been agreed upon, and levels vary enormously from study to study [ 13 , 16 , 17 ]. On comparing the pre-sensitization status of patients with different serum BAFF levels, we excluded patients with zero PRA levels as the BAFF levels in these patients may be related to other antibodies besides anti-HLA antibodies [ 18 ]. Our results show that higher pre-transplant BAFF levels are associated with higher prevalence of pre-transplant sensitization and increased early allograft rejection.…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of Pre- and Post-Transplant BAFF Levels in Kidney Transplant Recipients

Min

Kim

et al. 2016

PLoS ONE

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It is well known that pre-transplant B cell activating factor (BAFF) levels are associated with the development of de novo anti-HLA antibodies and antibody mediated rejection post-transplant. However, the clinical significance of BAFF values at allograft rejection has not been determined. In this study, we investigated the clinical significance of pre-transplant BAFF level as well as post-transplant BAFF levels measured when indication biopsy was done. We checked for anti-HLA antibodies in 115 kidney transplant recipients who required allograft biopsy due to an increase in serum creatinine. With the same serum specimen, we measured BAFF levels, and in 78 of these patients, pre-transplant BAFF and anti-HLA antibody levels were detected as well. Patients in each group were divided into tertiles according to BAFF levels. We investigated the relationship between BAFF levels and the occurrence of anti-HLA antibodies. Pre-transplant BAFF levels showed significant association with pre-transplant sensitization, and also with early rejection (Tertile 3, 26.9% vs. Tertile 1, 11.5%; P<0.05). Post-transplant BAFF levels showed significant association with pre-transplant sensitization, but did not show association with anti-HLA antibodies and positive donor-specific antibodies at the time of biopsy. We did not find any association between post-transplant BAFF levels and allograft biopsy results, Banff scores and microvascular inflammation scores. In conclusion, pre-transplant BAFF levels are associated with pre-transplant sensitization and are useful in predicting allograft rejection. But post-transplant BAFF levels measured at the time of indication biopsy are not associated with the appearance of de novo HLA-DSA, allograft rejection, biopsy findings and other allograft outcomes.

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“…50 Consequently, IL-17A is correlated with a proliferation-inducing ligand (APRIL). 51 In the SLEprone mouse model, BXD2, T H 17 cells reside in the GC and perpetuate autoimmunity, supporting a putative role in mediating humoral immunity. 52 T H 17 cell-related cytokines, IL-12, IL-17A and IL-23 are generally elevated in the serum of SLE patients.…”

Section: Follicular Helper T Cells and Subsetsmentioning

confidence: 97%

“…Although the classic function of T H 17 cells in SLE is to recruit neutrophils and create inflammation, 49 T H 17 cells can also provide effective B‐cell help and induce isotype switching 50 . Consequently, IL‐17A is correlated with a proliferation‐inducing ligand (APRIL) 51 . In the SLE‐prone mouse model, BXD2, T H 17 cells reside in the GC and perpetuate autoimmunity, supporting a putative role in mediating humoral immunity 52 …”

Section: Introductionmentioning

confidence: 99%

CC chemokine receptor 6 (CCR6) in the pathogenesis of systemic lupus erythematosus

Lee

Körner

2020

Immunol Cell Biol

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The CC chemokine receptor 6 (CCR6) and its sole chemokine ligand, CCL20, are an intriguing pair that have been implicated in a growing number of inflammatory, autoimmune and malignant disease processes. Recent observations have also highlighted this chemokine axis in the regulation of humoral immune responses. Through this review article, we explore the emerging links of CCR6-CCL20 with an archetypal autoimmune disease of humoral dysregulation: systemic lupus erythematosus (SLE). CCR6 is expressed prominently on several immune cells involved in the pathogenesis of SLE, such as dendritic cells and T-helper 17 cells. CCR6's expression is correlated with disease activity and serological markers of disease severity, suggesting a possible role in disease pathogenesis. However, there are numerous holes in our understanding of the functions of CCR6 and CCL20, and future studies are required to determine if there are any diagnostic, prognostic or monitoring roles for these important molecules.

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APRIL levels strongly correlate with IL-17 in systemic lupus erythematosus

Abstract: While both s-BAFF and s-APRIL levels are elevated in SLE patients, they reflect different immunologic and clinical pathways. The strong association between s-APRIL and IL-17 activation supports a role for Th17 helper cells in B cell activation in SLE.

Cited by 14 publications

References 37 publications

Cytokines in systemic lupus erythematosus: their role in pathogenesis of disease and possible therapeutic opportunities

Cytokines in systemic lupus erythematosus: their role in pathogenesis of disease and possible therapeutic opportunities

Clinical Significance of Pre- and Post-Transplant BAFF Levels in Kidney Transplant Recipients

CC chemokine receptor 6 (CCR6) in the pathogenesis of systemic lupus erythematosus

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