Aptamer-based assembly systems for SARS-CoV-2 detection and therapeutics

Dong, Yuhang; Wang, Jingping; Chen, Ling; Chen, Haonan; Dang, Shuangbo; Li, Feng

doi:10.1039/d3cs00774j

Chem. Soc. Rev.

2024

DOI: 10.1039/d3cs00774j

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Aptamer-based assembly systems for SARS-CoV-2 detection and therapeutics

Yuhang Dong,

Jingping Wang,

Ling Chen

et al.

Abstract: This review presents the recent progress on aptamers that have been explored for SARS-CoV-2 detection and therapeutics, wherein the construction principles and characteristics of aptamer-based assembly systems are systematically summarized.

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Cited by 7 publications

References 281 publications

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Yao,

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Subunit vaccines, significant in next‐generation vaccine development, offer precise targeting of immune responses by focusing on specific antigens. However, this precision often comes at the cost of eliciting strong and durable immunity, posing a great challenge to vaccine design. To address this limitation, recent advancements in nanoparticles (NPs) are utilized to enhance antigen delivery efficiency and boost vaccine efficacy. This review examines how the physicochemical properties of NPs influence various stages of the immune response during vaccine delivery and analyzes how different NP types contribute to immune activation and enhance vaccine performance. It then explores the unique characteristics and immune activation mechanisms of these NPs, along with their recent advancements, and highlights their application in subunit vaccines targeting infectious diseases and cancer. Finally, it discusses the challenges in NP‐based vaccine development and proposes future directions for innovation in this promising field.

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Nanoparticles in Subunit Vaccines: Immunological Foundations, Categories, and Applications

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et al. 2024

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Highly sensitive β-amyloid1–42 oligomer aptamer-based assay via dual cyclic amplifications of three-way catalytic hairpin assembly and palindrome polymerase reaction

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Aptamer-based assembly systems for SARS-CoV-2 detection and therapeutics

Abstract: This review presents the recent progress on aptamers that have been explored for SARS-CoV-2 detection and therapeutics, wherein the construction principles and characteristics of aptamer-based assembly systems are systematically summarized.

Cited by 7 publications

References 281 publications

Nanoparticles in Subunit Vaccines: Immunological Foundations, Categories, and Applications

Nanoparticles in Subunit Vaccines: Immunological Foundations, Categories, and Applications

Pattern recognition-based aptasensor array for discrimination of matrix effect

Highly sensitive β-amyloid1–42 oligomer aptamer-based assay via dual cyclic amplifications of three-way catalytic hairpin assembly and palindrome polymerase reaction

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