Aptamer‐based biosensors and application in tumor theranostics

Mo, Tong; Liu, Xiyu; Luo, Yiqun; Zhong, Liping; Zhang, Zhikun; Li, Tong; Gan, Lu; Liu, Xiuli; Li, Lan; Wang, Huixue; Sun, Xinjun; Fan, Dianfa; Qian, Zhangbo; Wu, Pan; Chen, Xiaoyuan

doi:10.1111/cas.15194

Cited by 45 publications

(16 citation statements)

References 84 publications

(145 reference statements)

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“…According to the type of response signal, it can be divided into the amperometric method, cyclic voltammetry, electrical impedance method, etc. [ 30 ]. Among them, the electrochemical aptasensors proposed by Han et al mainly have four structures, namely the target-induced structure switching mode, sandwich or sandwich-like mode, target-induced dissociation or displacement and competitive replacement mode [ 29 ].…”

Section: Classification Of Biosensorsmentioning

confidence: 99%

Recent Progress in Biosensors for Detection of Tumor Biomarkers

Jiang

Xue

et al. 2022

Molecules

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Cancer is a leading cause of death worldwide, with an increasing mortality rate over the past years. The early detection of cancer contributes to early diagnosis and subsequent treatment. How to detect early cancer has become one of the hot research directions of cancer. Tumor biomarkers, biochemical parameters for reflecting cancer occurrence and progression have caused much attention in cancer early detection. Due to high sensitivity, convenience and low cost, biosensors have been largely developed to detect tumor biomarkers. This review describes the application of various biosensors in detecting tumor markers. Firstly, several typical tumor makers, such as neuron-specific enolase (NSE), carcinoembryonic antigen (CEA), prostate-specific antigen (PSA), squamous cell carcinoma antigen (SCCA), carbohydrate, antigen19-9 (CA19-9) and tumor suppressor p53 (TP53), which may be helpful for early cancer detection in the clinic, are briefly described. Then, various biosensors, mainly focusing on electrochemical biosensors, optical biosensors, photoelectrochemical biosensors, piezoelectric biosensors and aptamer sensors, are discussed. Specifically, the operation principles of biosensors, nanomaterials used in biosensors and the application of biosensors in tumor marker detection have been comprehensively reviewed and provided. Lastly, the challenges and prospects for developing effective biosensors for early cancer diagnosis are discussed.

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Section: Classification Of Biosensorsmentioning

confidence: 99%

Recent Progress in Biosensors for Detection of Tumor Biomarkers

Jiang

Xue

et al. 2022

Molecules

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“…4 Most importantly, the design of aptamer sensors and mechanisms is based on three signal transduction modes, i.e., electrochemistry, colorimetry, and fluorescence, which are helpful in tumor theranostics and post-treatment monitoring. 5 Furthermore, cellulose-based flexible bioelectronic devices and their application in biomedicals have been emerged as climate neutral approach. 6 The advancements of materials play a significant role in the diagnosis, treatment, and disease prevention.…”

Section: Introductionmentioning

confidence: 99%

“…were important aspects that have been researched recently . Most importantly, the design of aptamer sensors and mechanisms is based on three signal transduction modes, i.e., electrochemistry, colorimetry, and fluorescence, which are helpful in tumor theranostics and post-treatment monitoring …”

Section: Introductionmentioning

confidence: 99%

Advances in Organ-on-a-Chip Materials and Devices

Nahak¹,

Mishra²,

Preetam³

et al. 2022

ACS Appl. Bio Mater.

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The organ-on-a-chip (OoC) paves a way for biomedical applications ranging from preclinical to clinical translational precision. The current trends in the in vitro modeling is to reduce the complexity of human organ anatomy to the fundamental cellular microanatomy as an alternative of recreating the entire cell milieu that allows systematic analysis of medicinal absorption of compounds, metabolism, and mechanistic investigation. The OoC devices accurately represent human physiology in vitro; however, it is vital to choose the correct chip materials. The potential chip materials include inorganic, elastomeric, thermoplastic, natural, and hybrid materials. Despite the fact that polydimethylsiloxane is the most commonly utilized polymer for OoC and microphysiological systems, substitute materials have been continuously developed for its advanced applications. The evaluation of human physiological status can help to demonstrate using noninvasive OoC materials in real-time procedures. Therefore, this Review examines the materials used for fabricating OoC devices, the application-oriented pros and cons, possessions for device fabrication and biocompatibility, as well as their potential for downstream biochemical surface alteration and commercialization. The convergence of emerging approaches, such as advanced materials, artificial intelligence, machine learning, three-dimensional (3D) bioprinting, and genomics, have the potential to perform OoC technology at next generation. Thus, OoC technologies provide easy and precise methodologies in cost-effective clinical monitoring and treatment using standardized protocols, at even personalized levels. Because of the inherent utilization of the integrated materials, employing the OoC with biomedical approaches will be a promising methodology in the healthcare industry.

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“…Aptamers can recognize a wide range of molecules, such as proteins, enzymes, toxins, or ions, and bind to these specific targets with high affinity and specificity. Aptamers have also been investigated as novel tools in targeted therapeutics, disease diagnostics, and imaging applications [ 6 , 7 , 8 ]. Furthermore, aptamers have a number of advantages over antibodies, such as higher thermal stability, ease of synthesis, no or minimum immunogenicity, high flexibility, and ease of modifying.…”

Section: Introductionmentioning

confidence: 99%

“…Multiple articles have thoroughly reviewed the theranostic application of aptamers as a targeting agent for cancer biomarkers [ 6 , 22 , 23 ]. Furthermore, beyond the mentioned aptamer applications, there has been increasing attention for integrating the CRISPR/Cas genetic editing technique.…”

Section: Introductionmentioning

confidence: 99%

An Update of Nucleic Acids Aptamers Theranostic Integration with CRISPR/Cas Technology

et al. 2022

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The clustered regularly interspaced short palindromic repeat (CRISPR)/Cas system is best known for its role in genomic editing. It has also demonstrated great potential in nucleic acid biosensing. However, the specificity limitation in CRISPR/Cas has created a hurdle for its advancement. More recently, nucleic acid aptamers known for their high affinity and specificity properties for their targets have been integrated into CRISPR/Cas systems. This review article gives a brief overview of the aptamer and CRISPR/Cas technology and provides an updated summary and discussion on how the two distinctive nucleic acid technologies are being integrated into modern diagnostic and therapeutic applications

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Aptamer‐based biosensors and application in tumor theranostics

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri butio n-NonCo mmerc ial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Cited by 45 publications

References 84 publications

Recent Progress in Biosensors for Detection of Tumor Biomarkers

Recent Progress in Biosensors for Detection of Tumor Biomarkers

Advances in Organ-on-a-Chip Materials and Devices

An Update of Nucleic Acids Aptamers Theranostic Integration with CRISPR/Cas Technology

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