Aptamer-based nanoparticles for cancer targeting

Abstract

We conclude that although further studies are required, the nanoparticle mesoporous silica model loaded with aptamer is very functional and its use can be widespread for other application especially in nuclear medicine.

Nucleic Acid Aptamer-Guided Cancer Therapeutics and Diagnostics: the Next Generation of Cancer Medicine

“…In addition, aptamers can also be conjugated with other nanostructures for targeted and high-payload cancer therapy, such as single-walled carbon nanotubes, bovine serum albumin-based NPs, dendrimers and mesoporous silica nanoparticles 128 - 132 (Table 3 ). However, more studies on potential toxicity and in vivo fate of the nano-carriers are needed before successful translation of aptamer-nano-drugs from bench to bedside.…”

Nano-Aptamer for Breast Cancer Imaging: Initial Considerations

“…Furthermore, this opens up the possibility for future study in developing cancer models [5,[10][11][12][13][14][15][16][17][18][19].…”

Anti-MUC1 nano-aptamers for triple-negative breast cancer imaging by single-photon emission computed tomography in inducted animals: initial considerations

“…The method used was the direct labeling process as described by Sá et al 26 and Albernaz et al 34 The labeling process used 150 μL of NPs (empty and loaded), which were incubated with SnCl 2 solution (30 μL/mL) (Sigma-Aldrich, St Louis, MO, USA) for 20 minutes at room temperature. Then this solution was incubated with 2 mCi (~300 μL) of Tc.…”

“…The results were expressed as uCiper organ. 26,34 sPecT imaging Planar images were obtained at 90 minutes after injection of nano-radiopharmaceuticals (3.7 MBq in volume of 0.2 mL) using a Millenium Gamma Camera (GE Healthcare, Cleveland, OH, USA). Counts were acquired for 5 minutes in a 15% window centered at 140 keV.…”

“…[21][22][23] Furthermore, they have been shown to be particularly promising agents in photodynamic therapy as phototoxic agents 24 and delivery agents of standard chemotherapy such as doxorubicin. 25 Finally, the MUC1 aptamers have been successfully used in nanoparticle (NP) formulation, described both from our own group 26 for silica NPs and from a different group for liposomal formulation in conjunction with paclitaxel. 27 The properties of high affinity and specificity toward their targets make aptamers the molecules of choice to be used as delivery agents.…”