Aptamer-Functionalized DNA Nanostructures for Biological Applications

Fu, Xiaoyi; Peng, Fangqi; Lee, Jungyeon; Yang, Qi; Zhang, Fei; Xiong, Mengyi; Kong, Gezhi; Meng, Hong Min; Ke, Guoliang; Zhang, Xiao Bing

doi:10.1007/s41061-020-0283-y

Cited by 31 publications

(21 citation statements)

References 175 publications

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“…Molecular biosensing plays a critical role in disease diagnosis, drug monitoring, and toxin detection (Jung et al, 2017; Khajouei et al, 2020; J. Liu, 2011; N. Xu et al, 2020). As aptamers possess heightened specificity, affinity, and stability in comparison to other recognition molecules, they have received tremendous attention for molecular biosensing applications (Fu et al, 2020; J. Liu et al, 2012). Aptamer‐functionalized hydrogels have the characteristics of both aptamers and hydrogels.…”

Section: Biosensingmentioning

confidence: 99%

“…An ideal biosensor would combine highly sensitive and rapid detection of target molecules with instrument‐free visual output. Thus, naked‐eye detection has attracted much interest in the biosensing field (Fu et al, 2020; Khimji et al, 2013; J. Liu et al, 2012). Aptamer‐functionalized hydrogels are promising for the development of portable, visual molecular biosensors, as these biosensors exploit changes to the hydrogel network to generate visual signals without involving complicated instruments.…”

Section: Biosensingmentioning

confidence: 99%

“…Xu et al, 2020). As aptamers possess heightened specificity, affinity, and stability in comparison to other recognition molecules, they have received tremendous attention for molecular biosensing applications (Fu et al, 2020;. Aptamer-functionalized hydrogels have the characteristics of both aptamers and hydrogels.…”

Section: Biosensingmentioning

confidence: 99%

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Aptamer‐functionalized hydrogels: An emerging class of biomaterials for protein delivery, cell capture, regenerative medicine, and molecular biosensing

Abune

Davis

Wang

2021

WIREs Nanomed Nanobiotechnol

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Molecular recognition is essential to the development of biomaterials. Aptamers are a unique class of synthetic ligands interacting with not only their target molecules with high affinities and specificities but also their complementary sequences with high fidelity. Thus, aptamers have recently attracted significant attention in the development of an emerging class of biomaterials, that is, aptamer‐functionalized hydrogels. In this review, we introduce the methods of incorporating aptamers into hydrogels as pendant motifs or crosslinkers. We further introduce the functions of these hydrogels in recognizing proteins, cells, and analytes through four applications including protein delivery, cell capture, regenerative medicine, and molecular biosensing. Notably, as aptamer‐functionalized hydrogels have the characteristics of both aptamers and hydrogels, their potential applications are broad and beyond the scope of this review. This article is categorized under: Biology‐Inspired Nanomaterials > Nucleic Acid‐Based Structures Implantable Materials and Surgical Technologies > Nanomaterials and Implants Therapeutic Approaches and Drug Discovery > Emerging Technologies

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Section: Biosensingmentioning

confidence: 99%

Section: Biosensingmentioning

confidence: 99%

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Aptamer‐functionalized hydrogels: An emerging class of biomaterials for protein delivery, cell capture, regenerative medicine, and molecular biosensing

Abune

Davis

Wang

2021

WIREs Nanomed Nanobiotechnol

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“…The rapid advancement in fabrication technologies (Liang et al, 2019;Fu et al, 2020) as well as experimental design (Beenakker and van Houten, 1991;Kim and Olendski, 1996) has led to a great deal of renewed interest in the interactions of confined electrons with the various crystal excitations, especially in semiconductors (Peeters and De Boeck, 1999). The renewed interest is in part stimulated by potential device applications (Fu et al, 2020;Khalef et al, 2020;Beretta et al, 2020), which mainly rely on reduced phase space of the charge carriers (Sakaki, 1980). As such, the nature of other physical quantum mechanical quantities depends on the specific dynamics of the confined electrons, which in turn is largely determined by the overall potential of a given system.…”

Section: Introductionmentioning

confidence: 99%

Electron-LO-phonon Intrasubband Scattering Rates in a Hollow Cylinder Under the Influence of a Uniform Axial Applied Magnetic Field

Masale

Tshipa

2021

Preprint

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Scattering rates arising from the interactions of electrons with bulk longitudinal optical (LO) phonon modes in a hollow cylinder are calculated as functions of the inner radius and the uniform axial applied magnetic field. Now, the specific nature of electron-phonon interactions mainly depends on the character of the energy spectrum of electrons. As is well known, in cylindrical quantum wires, the application of a parallel magnetic field lifts the double degeneracy of the non-zero azimuthal quantum number states; m≠0; irrespective of all electron's radial quantum number l states. In fact, this Zeeman splitting is such that the m < 0 electron's energy subbands initially decrease with the increase of the parallel applied magnetic field. In a solid cylinder, the lowest-order; {l = 1; m = 0} subband is always the ground state. In a hollow cylinder, however, as the axial applied magnetic field is increased, the electron's energy subbands take turns at becoming the ground state; following the sequence {m=0,-1,-2...-N} of azimuthal quantum numbers. Furthermore, in a hollow cylinder, in general, the electron's energy separations between any two subbands are less than the LO phonon energy except for exceptionally high magnetic fields, and some highest-order quantum number states. In view of this, the discussion of the energy relaxation here is focused mainly on intrasubband scattering of electrons and only within the lowest-order {l = 1; m = 0} electron's energy subband. The intrasubband scattering rates are found to be characterized by shallow minima in their variations with the inner radius, again, for a fixed outer radius. This feature is a consequence of a balance between two seemingly conflicting effects of the electron's confinement by the inner and outer walls of the hollow cylinder. First; increased confinement of the charge carriers generally leads to the enhancement of the rates. Second; the presence of a hole in a hollow cylinder leads to a significant suppression of the scattering rates. The intrasubband scattering rates also show a somewhat parabolic increase in their variations with the applied magnetic field; an increase which is more pronounced in a relatively thick hollow cylinder.

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“…The use of AuNPs as versatile and efficient templates for the immobilization of biomolecules has been recognized for decades 21 . The interaction of AuNPs with proteins/DNA has received great attention for colorimetric detection 22,23 . However, in our best of knowledge, no colorimetric sensing approach has been reported using passive absorption of an enzyme with AuNPs.…”

Section: Introductionmentioning

confidence: 99%

Monitoring of whitening agent for skin analysis using tyrosinase gold nanoparticle‐based colorimetric assay

Siddiqui

Jeon

Kim

2020

Asia-Pacific J Chem Eng

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Arbutin is a potential depigmenting agent that reduces melanin production by inhibiting tyrosinase activity and predicts the risk of whitening of the skin. Despite wide acceptance in routine laboratory tests, the conventional methods for whitening agent analysis have been of limited use because of high cost and lower signal sensitivity. Gold nanoparticles have gained considerable interest in improving the sensitivity and signals for the detection of proteins. Inspiring from these strategies, we have designed a tyrosinase enzyme gold nanoparticles (tyrosinase–AuNPs) method for the evaluation of arbutin with improved signals. The developed assay has been tested for tyrosine spiked samples to derive the standard graph. And then the performance of the assay is validated by testing arbutin on inhibiting tyrosinase activity. A detection limit of 13.70 μM with R2 of 0.982 is confirmed. Compared with the conventional method, the proposed assay represented the improved sensitivity, and signals are enhanced by five times that can be easily visualized through the naked eyes. Moreover, our method is beneficial because of the low cost and avoiding the need for expensive instruments. We believe that this method for arbutin evaluation will provide a foundation for the screening of other whitening agents, paving the way for future advances in the field of cosmetics.

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Aptamer-Functionalized DNA Nanostructures for Biological Applications

Cited by 31 publications

References 175 publications

Aptamer‐functionalized hydrogels: An emerging class of biomaterials for protein delivery, cell capture, regenerative medicine, and molecular biosensing

Aptamer‐functionalized hydrogels: An emerging class of biomaterials for protein delivery, cell capture, regenerative medicine, and molecular biosensing

Electron-LO-phonon Intrasubband Scattering Rates in a Hollow Cylinder Under the Influence of a Uniform Axial Applied Magnetic Field

Monitoring of whitening agent for skin analysis using tyrosinase gold nanoparticle‐based colorimetric assay

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