Aptamer-modified CuS nanocrystals/graphene oxide composites for controlled release of glucosamine and chemo-photothermal therapy of tumor cells

Xu, Ziqing; Wu, Shicheng; Huang, Guojin; Ding, Hongwei; Gui, Rijun; Zhu, Baohua

doi:10.1016/j.matlet.2017.02.119

Cited by 12 publications

(3 citation statements)

References 20 publications

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“…High concentrations of glucosamine or its derivatives can inhibit certain tumor cells. 85 Those findings are favorable in developing new drugs for the treatment of cancer, thus the detection of glucosamine is particularly important. Tam Minh Tran et al reported a novel sensor 35 for glucosamine.…”

Section: Carbohydrates Boronic Acid Sensorsmentioning

confidence: 99%

Recent development of boronic acid-based fluorescent sensors

et al. 2018

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As Lewis acids, boronic acids can bind with 1,2-or 1,3-diols in aqueous solution reversibly and covalently to form five or six cyclic esters, thus resulting in significant fluorescence changes. Based on this phenomenon, boronic acid compounds have been well developed as sensors to recognize carbohydrates or other substances. Several reviews in this area have been reported before, however, novel boronic acid-based fluorescent sensors have emerged in large numbers in recent years. This paper reviews new boronbased sensors from the last five years that can detect carbohydrates such as glucose, ribose and sialyl Lewis A/X, and other substances including catecholamines, reactive oxygen species, and ionic compounds. And emerging electrochemically related fluorescent sensors and functionalized boronic acid as new materials including nanoparticles, smart polymer gels, and quantum dots were also involved.By summarizing and discussing these newly developed sensors, we expect new inspiration in the design of boronic acid-based fluorescent sensors.

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Section: Carbohydrates Boronic Acid Sensorsmentioning

confidence: 99%

Recent development of boronic acid-based fluorescent sensors

et al. 2018

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“…S1 ). CuS nanomaterials, as typical photothermal agents, have been widely studied in biomedical application [ 35 , 36 ]. Consequently, the photothermal performance of the CuS NPs was carefully investigated via recording the changes of the temperature under NIR (808 nm) laser irradiation.…”

Section: Resultsmentioning

confidence: 99%

Biocompatible copper sulfide–based nanocomposites for artery interventional chemo-photothermal therapy of orthotropic hepatocellular carcinoma

Tian

Tang

et al. 2021

Materials Today Bio

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Transcatheter arterial embolization has been considered as a promising targeted delivery approach for hepatocellular carcinoma (HCC). Currently, chemoembolization was the main treatment for unresectable HCC. However, the traditional chemoembolization treatment suffers from undesirable therapeutic effects and serious side-effects. In this study, the doxorubicin (DOX)-encapsulated and near-infrared (NIR)–responsible copper sulfide (CuS)–based nanotherapeutics was developed for magnetic resonance imaging (MRI)–guided chemo-photothermal therapy of HCC tumor in rats. The DOX-loaded CuS nanocomposites (DOX@BSA-CuS) demonstrated distinct NIR-triggered drug release behavior and high photothermal effect. In an orthotopic HCC rat model, DOX@BSA-CuS nanocomposites were selectively delivered to the tumor site via the intra-arterial transcatheter. The proposed DOX@BSA-CuS nanocomposites plus NIR laser irradiation exhibited significant tumor growth suppression performance. Moreover, the treatment progress can be monitored by MRI images. Finally, the preliminary toxicity estimate suggested the negligible side-effect of DOX@BSA-CuS nanocomposites during the therapeutic process. These results suggest the clinical translational potential possibility for imaging-guided arterial embolization with DOX@BSA-CuS nanocomposites for the treatment of HCC.

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“…In order to improve the tumor inhibition ability, anti-tumor drugs are usually loaded on photothermal agents to fabricate drug-loaded system [ 19 ]. On the one hand, photothermal agent can present PTT effect under NIR laser irradiation.…”

Section: Introductionmentioning

confidence: 99%

Photothermal/pH Dual-Responsive Drug Delivery System of Amino-Terminated HBP-Modified rGO and the Chemo-Photothermal Therapy on Tumor Cells

et al. 2018

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In this paper, a simple method to prepare hydrophilic reduced graphene oxide (rGO) was proposed via reducing GO by amino-terminated hyperbranched polymer (NHBP), the as-prepared NrGO could present excellent dispersibility, near infrared (NIR) light absorbance, photothermal conversion ability and stability. Then, the doxorubicin hydrochloride (DOX) was conjugated with NrGO to prepare the drug-loading system, and a pH/photothermal dual-responsive drug delivery behavior was characterized. At acidic environment or under NIR laser irradiation, the drug release rate could be improved, which is beneficial to control release anti-tumor drug in tumor tissues. What is more, the in vitro cell experiments revealed that NrGO was well biocompatible, and in the tumor inhibition part, comparing to the control group without any treatment, DOX@NrGO gained efficient chemo-photothermal synergetic therapy, the inhibition rate of which was much higher than single chemotherapy of released DOX. Therefore, the as-prepared DOX@NrGO obtained great potential application in tumor therapy and an excellent candidate in other biomed applications.

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Aptamer-modified CuS nanocrystals/graphene oxide composites for controlled release of glucosamine and chemo-photothermal therapy of tumor cells

Cited by 12 publications

References 20 publications

Recent development of boronic acid-based fluorescent sensors

Recent development of boronic acid-based fluorescent sensors

Biocompatible copper sulfide–based nanocomposites for artery interventional chemo-photothermal therapy of orthotropic hepatocellular carcinoma

Photothermal/pH Dual-Responsive Drug Delivery System of Amino-Terminated HBP-Modified rGO and the Chemo-Photothermal Therapy on Tumor Cells

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