2020
DOI: 10.1007/s10493-020-00471-9
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Apyrase with anti-platelet aggregation activity from the nymph of the camel tick Hyalomma dromedarii

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Cited by 10 publications
(6 citation statements)
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“…Apyrase has been identified in the saliva of most haematophagous vectors, including soft and hard ticks. This enzyme hydrolyses ATP and ADP to AMP, and prevents platelet and neutrophil aggregation and thrombus formation, thus facilitating blood feeding [ 47 , 48 ]. A recombinant form of the salivary apyrase of O. moubata induced protective, strong humoral responses in animal vaccine trials that reduced tick feeding and survival [ 47 ].…”
Section: Resultsmentioning
confidence: 99%
“…Apyrase has been identified in the saliva of most haematophagous vectors, including soft and hard ticks. This enzyme hydrolyses ATP and ADP to AMP, and prevents platelet and neutrophil aggregation and thrombus formation, thus facilitating blood feeding [ 47 , 48 ]. A recombinant form of the salivary apyrase of O. moubata induced protective, strong humoral responses in animal vaccine trials that reduced tick feeding and survival [ 47 ].…”
Section: Resultsmentioning
confidence: 99%
“…albopictus and other hematophagous arthropods during blood feeding that functions as platelet aggregation inhibitor. (25) The 67 kDa molecular weight protein in our study is thought to contain apyrase and α-glucosidase. The latter acts as an allergen that will induce IgE in humans.…”
Section: Discussionmentioning
confidence: 74%
“…The D7 family functions as a vasodilator, immunomodulator, and anticoagulant. (33) The protein of 47 kDa is serpin, that acts as anticoagulant and anti-inflammatory, (23,25,26) where as the band of 67 kDa is apyrase, that acts as allergen and anticoagulant. The abovementioned three proteins are thought to trigger modulation of the host's immune response because they comprise proteins that act as allergens and immunomodulators.…”
Section: Discussionmentioning
confidence: 99%
“…Apyrase has been identi ed in the saliva of most hematophagous vectors including soft and hard ticks. It is an enzyme that hydrolyses ATP and ADP to AMP and prevents platelet and neutrophil aggregation and thrombus formation, facilitating blood feeding [46,47]. A recombinant form of the salivary apyrase of O. moubata induced protective, strong humoral responses in animal vaccine trials that reduced tick feeding and survival [46].…”
Section: Quanti Cation Of the Proteins Identi Ed In The Female And Male Saliva By Swath-msmentioning
confidence: 99%