Aquacel Ag® in the Management of Partial-Thickness Burns: Results of a Clinical Trial

Abstract

Aquacel Hydrofiber is a moisture retentive topical dressing that has been demonstrated to be safe and efficacious for the management of partial-thickness burns, showing parity for most dressing related aspects to cadaver skin for this indication. Recently, 1.2% w/w silver has been added to the Aquacel Hydrofiber, to create Aquacel Ag. This new material releases silver within the dressing for up to two weeks, and it is this duration that differentiates it from other sustained release silver delivery products indicated for burn management. The dressing was tested in a phase II noncomparative trial in superficial, mid dermal, and mixed partial-thickness burns. Percentage and speed of reepithelialization were satisfactory and appear to be similar at least to results noted with silver sulfadiazine, although, no direct comparisons were performed in this study. Pain reduction between baseline and postburn day number three and five was statistically significant. Conformability, general ease of use and other functional dressing properties were rated very positively. Overall, Aquacel Ag combines several properties known to be beneficial for the management of partial-thickness burns and is a very good choice for superficial and mid-thickness burn injuries.

Effects of silver nanoparticles in combination with antibiotics on the resistant bacteria <em>Acinetobacter baumannii</em>

“…[10][11][12] The antibacterial activity of silver nanoparticles (AgNPs) had been reported against multiple species of bacteria; for example, Escherichia coli ATCC 8739, 13 Staphylococcus aureus ATCC1431, 14 Escherichia fergusonii, and Klebsiella aerogenes ATCC…”

Cost of nursing most frequent procedures performed on severely burned patients

“…Therefore, it is the responsibility of health professionals to choose between passive (inert) bandages and bandages with active principles. In cases of burn injuries, silver-based active bandages are more effective coverage because they require less changes and exhibit a prolonged antibacterial effect (25)(26) . According to an international research carried out in 2010 in a burn ICU, the mean daily cost of using silver dressings (ACTICOAT 7 Antimicrobial Barrier Dressing) was AUD$ 120.77 (2) .…”

AQUACEL® Ag BURN glove and silver sulfadiazine for the treatment of partial thickness hand burns: A retrospective review

“…Duteille and Jeffery [3] reported the initial application of the glove to be very easy/easy in 87% of cases with reapplication of the glove very easy/easy in 95% of cases. Caruso et al [14] also reported ease of application using AQUACEL ® Ag in the management of partial thickness burns, with 82% reporting very easy to apply and 18% easy to apply.…”

“…[6,9] In particular, the use of SSD achieved greater flexibility and ROM when compared to AQUACEL ® Ag for burn wounds. [9] Caruso et al [14] found the flexibility excellent to very good in the 82% of patients with 19% reporting average to poor flexibility. Duteille and Jeffery [3] reported that on initial application of the AQUACEL ® Ag glove, flexibility was either good or excellent reporting 83% at 24 h; however, this reduced to 56% at the final evaluation.…”