Aqueous root extracts from Mimosa albida Humb. &amp; Bonpl. ex Willd display antinociceptive activity in mice

Rejón-Orantes, J.C.; Suarez, Dominic; Rejón-Rodríguez, A.; Hernandez, Steve; Liévano, O.E. García; Rodriguez, Daylin; Mora, Miguel Pérez de la

doi:10.1016/j.jep.2013.07.010

Cited by 17 publications

(16 citation statements)

References 24 publications

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“…bradykinin, histamine and serotonin), cytokines (e.g. TNF‐α and IL‐1β) and chemokines that excite the nerve endings [47]. Thus, the inhibitory effect of PFPe observed in this model is due in part to modulation of the release of these inflammatory mediators and stabilization of mast cell membrane, and corroborates with our previous results of paw oedema, vascular permeability and IL‐1β levels.…”

Section: Discussionsupporting

confidence: 92%

Polysaccharide fraction isolated from P assiflora edulis inhibits the inflammatory response and the oxidative stress in mice

Silva

Damasceno

Brito

et al. 2015

Journal of Pharmacy and Pharmacology

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Section: Discussionsupporting

confidence: 92%

Polysaccharide fraction isolated from P assiflora edulis inhibits the inflammatory response and the oxidative stress in mice

Silva

Damasceno

Brito

et al. 2015

Journal of Pharmacy and Pharmacology

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“…In pharmacological investigations, Mimosa species are mainly characterised by their antioxidant potential [4,9] and antimicrobial activity [10,11]. However, studies investigating acetylcholinesterase [12], antiulcerogenic [13], antidiabetic [14], anti-inflammatory [15], antifungal [16], antinociceptive [17] and cytotoxic effects [18] of Mimosa species have also been described.…”

Section: Introductionmentioning

confidence: 99%

Assessing Chemical Constituents of Mimosa caesalpiniifolia Stem Bark: Possible Bioactive Components Accountable for the Cytotoxic Effect of M. caesalpiniifolia on Human Tumour Cell Lines

et al. 2015

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Mimosa caesalpiniifolia is a native plant of the Brazilian northeast, and few studies have investigated its chemical composition and biological significance. This work describes the identification of the first chemical constituents in the ethanolic extract and fractions of M. caesalpiniifolia stem bark based on NMR, GC-qMS and HRMS analyses, as well as an assessment of their cytotoxic activity. GC-qMS analysis showed fatty acid derivatives, triterpenes and steroid substances and confirmed the identity of the chemical compounds isolated from the hexane fraction. Metabolite biodiversity in M. caesalpiniifolia stem bark revealed the differentiated accumulation of pentacyclic triterpenic acids, with a high content of betulinic acid and minor amounts of 3-oxo and 3β-acetoxy derivatives. OPEN ACCESSMolecules 2015, 20 4205Bioactive analysis based on total phenolic and flavonoid content showed a high amount of these compounds in the ethanolic extract, and ESI-(−)-LTQ-Orbitrap-MS identified caffeoyl hexose at high intensity, as well as the presence of phenolic acids and flavonoids. Furthermore, the evaluation of the ethanolic extract and fractions, including betulinic acid, against colon (HCT-116), ovarian (OVCAR-8) and glioblastoma (SF-295) tumour cell lines showed that the crude extract, hexane and dichloromethane fractions possessed moderate to high inhibitory activity, which may be related to the abundance of betulinic acid. The phytochemical and biological study of M. caesalpiniifolia stem bark thus revealed a new alternative source of antitumour compounds, possibly made effective by the presence of betulinic acid and by chemical co-synergism with other compounds.

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“…identified as catechin derivatives, which are substances that exhibit potent antioxidant activity with the elimination of free radicals and are anticarcinogenic anti-inflammatory agents, antidiarrheal, and antimutagenic. 12,28,29 The other ions detected were also subjected to experiments of MS/MS. In some cases, the spectra showed fragment ions m/z 303 or 287, referring to the glycosylated flavonoid and aglycones.…”

Section: Resultsmentioning

confidence: 99%

“…3 In addition, several other Mimosa species have been also used to treat other diseases. 12 Mimosa pudica is used in the treatment of a variety of medical problems including anthelmintic action, 13 antiinflammatory properties 14 and the root extract contains high levels of antioxidants. Mimosa tenuiflora is a popular remedy utilized in Mexico and Brazil, the bark of this plant once dried, powdered, and directly applied to the lesion is an effective remedy for treating skin burns and wounds and preventing inflammation 15,16 Mimosa hostilis is used against cough and for wound healing.…”

Section: Introductionmentioning

confidence: 99%

Mimosa caesalpiniifolia (Fabaceae), a medicinal plant from Brazilian cerrado with antioxidant and antiinflammatory properties

José¹,

Beserra²,

Rodrigues³

et al. 2021

IJCAM

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Ethnopharmacological relevance: Mimosa caesalpiniifolia popularly known as "sabiá" or "sansão-do-campo" is a Brazilian Northeast native perennial tree used for several purposes and in traditional medicine is used for inflammatory diseases, hypertension and fungal infections.Aim of the study: The objective of this study was to identify the compounds in the hydroalcoholic extract of EEM leaves encapsulated with aerosil ® 20%, and to evaluate their antioxidant and anti-inflammatory. Material and methods:The antioxidant activity of EEM leaf hydroalcoholic extract was determined by using both the 1,1-diphenyl-2-picrylhydrazyl radical scavenging and the oxygen radical absorbance capacity in vitro assay. The phytochemical study of EEM was analyzed by experiments with FIA-ESI-IT-MS n (Direct Flow Analysis-ionization Electrospray Ion Trap Tandem Mass Spectrometry). Anti-inflammatory properties of EEM were evaluated in ear edema induced by xylene in rats. Results:The phytochemical investigation of EEM resulted in the identification of flavonoids glycosides (m/z 563, 579, 621) and derivatives of catechin (m/z 595, 611, 741 and 757). EEM leaf extract had antioxidant and anti-inflammatory properties. EEM (125 and 250mg/kg, p.o.) significantly inhibited the ear edema induced by xylene (52% and 64% respectively). Conclusion:Our results suggest the antioxidant action and the anti-inflammatory effect in the mouse ear edema model of EEM are related to the presence of flavonoids and catechin derivatives revealed in phytochemical screening. These results support the ethnopharmacological use of Mimosa caesalpiniifolia in folk medicine.

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Aqueous root extracts from Mimosa albida Humb. & Bonpl. ex Willd display antinociceptive activity in mice

Cited by 17 publications

References 24 publications

Polysaccharide fraction isolated from P assiflora edulis inhibits the inflammatory response and the oxidative stress in mice

Polysaccharide fraction isolated from P assiflora edulis inhibits the inflammatory response and the oxidative stress in mice

Assessing Chemical Constituents of Mimosa caesalpiniifolia Stem Bark: Possible Bioactive Components Accountable for the Cytotoxic Effect of M. caesalpiniifolia on Human Tumour Cell Lines

Mimosa caesalpiniifolia (Fabaceae), a medicinal plant from Brazilian cerrado with antioxidant and antiinflammatory properties

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