Arctium lappa Lam. and Its Related Lignans Improve Hyperglycemia and Dyslipidemia in Diabetic Rodent Models: A Systematic Review and Meta-Analysis

Abstract

Research on nutraceuticals has focused on reducing the onset, progression, and significant consequences of diabetes mellitus. Arctium lappa Lam. is a great source of plant fibers and polyphenols that have anti-disease benefits, including those for diabetes mellitus. This study sought to determine the impact of Arctium lappa Lam. extracts and its associated lignans on diabetic hyperglycemia and dyslipidemia by conducting meta-analyses of the available research using diabetic rodents. English-language peer-reviewed articles were searched by PubMed and Embase up until 10 August 2022. Included were studies comparing the blood glucose and/or lipid levels of diabetic rodents given either extracts of Arctium lappa Lam. and its related lignans or vehicles. Blood glucose levels were reported in 16 studies involving 168 diabetic mice or rats treated with Arctium lappa Lam. and 168 diabetic controls. The pooled effect size was −1.42 [95% CI: −1.84 to −1.00] with significant heterogeneity. Type of diabetic model was found to be the prominent covariate that explained, at least partially, the heterogeneity. Moreover, diabetic rodents treated with Arctium lappa Lam. showed a notable improvement in their hypertriglyceridemia and hypercholesterolemia.

The Role of Burdock and Black Radish Powders Obtained by Low-Temperature Drying in Emulsion-Type Hair Conditioners

“…Burdock is also rich in vitamins B1, B2, C and A, and contains minerals including magnesium, sodium, potassium, calcium, zinc, copper, and iron. Based on the presence of active ingredients, multiple scientific studies have shown burdock to have prebiotic (inulin in the root) [9], antioxidant (caffeic acid in the stems, leaves, and rhizodermis) [10], antibacterial (betaeudesmol in the fruit) [11], and anticancer (tannin in the root, and arctin in the leaves, fruit and root) properties. In addition, burdock shows favorable dermatological properties.…”