Are cavum septum pellucidum abnormalities more common in schizophrenia spectrum disorders? A systematic review and meta-analysis

Incidental Findings in Youths Volunteering for Brain MRI Research

“…Several studies suggest that the presence of a cavum septum pellucidum is significantly correlated with psychotic symptoms, also more prevalent in males. Whereas a recent meta-analysis by Trzesniak et al 8 suggested that only a "large" cavum was associated with schizophrenia spectrum disorders, in our sample we found significantly greater incidence of reporting psychotic symptoms in the subsample with cavum septum pellucidum. However, the small sample size precludes establishing a correlation between symptom severity and septum size.…”

“…Analyses were implemented by use of R software (version 2.15.0, http://www.r-project.org/). 14 To test the hypothesis of increased psychotic features in patients with cavum septum pellucidum, 8 we compared individuals with this incidental finding with participants from the larger sample who matched most closely on age, sex, and race. Specifically, each subject was paired with all participants in the sample who had the same values on these demographics.…”

“…For example, children with developmental delay of unknown etiology, according to retrospective chart reviews, were more likely (1.8 odds ratio) to have incidental findings than healthy control subjects. 7 In a recent meta-analysis, Trzesniak et al 8 concluded that the presence of a large cavum septum pellucidum is associated with schizophrenia spectrum disorders. However, no study has examined whether a finding of cavum septum pellucidum in an epidemiologically accrued sample is associated with increased incidence of psychotic features.…”

Management of Intracranial Incidental Findings on Brain MRI

“…In all weightings, the changes appear as fluid-isointense in the MRI. Even though associations with various neurological disorders have been described [12], such changes do not require further clarification (Category I). Between 6 -10 % of all examinations exhibit limited asymmetry of the ventricular system (• ▶ Fig.…”

Cavum Septum Pellucidum: Hallazgo Mediante Disección Neuroanatómica

“…En un estudio realizado de manera aleatoria al investigar la incidencia post mortem del cavum septum pellucidum en 500 cadáveres que oscilaban entre 14 y 89 años, se determinó entre otros, que esta cavidad es una anormalidad de estructuras de la línea mediana algunas veces asociadas con desórdenes y trastornos mentales (Filipovic et al). Otro estudio de meta análisis de 1054 pacientes con esquizofrenia contra 886 voluntarios normales, demostró que la incidencia de dicho espectro era significativamente alta en personas que poseían un amplio cavum septum pellucidum (Trzesniak et al, 2011). El cavum septum pellucidum se encuentra en todos los neonatos y comienza a cerrarse poco antes del nacimiento en los nacidos a término y a menudo se observa en las imágenes cerebrales obtenidas por tomografía computarizada y resonancia magnética nuclear, sólo el 6% llega a presentarse más allá de los 6 meses de edad (Afifi & Bergman).…”