Are Heart Muscle Irisin Levels and FNDC5 Gene Expression Regulated by Endurance and Resistance Exercises?

Hosseinzadeh, M.; Lamir, Amir Rashid; Hejazi, Seyed Mahmud

doi:10.29252/aassjournal.6.1.21

Cited by 5 publications

(1 citation statement)

References 41 publications

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“…Exercise is a strong stimulator for the production of FNDC5/ irisin in cardiac tissue (130)(131)(132), and the exercise-induced changes in irisin are associated with heart diseases (10,133). Aydin et al reported that irisin is highly presented in myocardium of both sedentary and exercise young rats, and it increased particularly in the connective tissues of heart after acute exercise (134).…”

Section: Fndc5/irisin-pink1/pakin-lc3ii/i-p62 Pathway In Exercise And...mentioning

confidence: 99%

Irisin at the crossroads of inter-organ communications: Challenge and implications

Zhao

2022

Front. Endocrinol.

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The physiological functions of organs are intercommunicated occurring through secreted molecules. That exercise can improve the physiological function of organs or tissues is believed by secreting myokines from muscle to target remote organs. However, the underlying mechanism how exercise regulates the inter-organ communications remains incompletely understood yet. A recently identified myokine–irisin, primarily found in muscle and adipose and subsequently extending to bone, heart, liver and brain, provides a new molecular evidence for the inter-organ communications. It is secreted under the regulation of exercise and mediates the intercommunications between exercise and organs. To best our understanding of the regulatory mechanism, this review discusses the recent evidence involving the potential molecular pathways of the inter-organ communications, and the interactions between signalings and irisin in regulating the impact of exercise on organ functions are also discussed.

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Section: Fndc5/irisin-pink1/pakin-lc3ii/i-p62 Pathway In Exercise And...mentioning

confidence: 99%

Irisin at the crossroads of inter-organ communications: Challenge and implications

Zhao

2022

Front. Endocrinol.

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Expression, Purification, and Antiserum Production of the Truncated UL31 Protein of Herpes Simplex Virus 1

et al. 2019

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Background The UL31 protein of herpes simplex virus 1 (HSV-1) plays an important role in the HSV-1 replication, however, its pinpoint functions in the life cycle of the virus have yet to be adequately elucidated. Objectives An antiserum specific for detecting HSV-1 UL31 was prepared as the foundation for future research on the role of UL31 in the course of HSV-1 infection. Materials and Methods Recombinant protein of UL31 was expressed in Escherichia coli , which was then purified and employed to raise the level of antiserum in mice. Subsequently, western blot and immunofluorescence assay (IFA) were utilized to detect the specific antiserum. Results The recombinant UL31 protein consisting of N-terminal 27 aa of UL31 was fused to EYFP and His-tag. It was expressed, purified, and applied to the preparation of the antiserum. Western blot analysis and IFA demonstrated that this antiserum could detect both the recombinant UL31 and the native UL31. Conclusions Our results manifest that this antiserum could be conducive to further investigations concerning the roles of UL31 in the HSV-1 infection.

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Poly-β-hydroxybutyrate Production by Methylosinus trichosporium OB3b at Different Gas-phase Conditions

Zhang

Wang

2019

IRAN J BIOTCH

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Background The utilization of methane for production of Poly-β-hydroxybutyrate (PHB) not only cuts the emissions of greenhouse gases but also greatly reduces PHB production cost. Objectives The aim of this study was to determine the effects of gas-phase conditions on PHB production by Methylosinus trichosporium OB 3 b. Materials and Methods Bacterial cultivation and PHB production were conducted in a series of sealed serum bottles. Nitrogen-free mineral salts medium was used to induce PHB production in the presence or absence of N 2 in the headspace. Results In the absence of N 2 , the highest PHB content (i.e., 52.9% of the dry cell weight with a PHB concentration of 814.3 mg.L -1 ) was obtained at a ratio of CH 4 :O 2 =2:1. Further study at different O 2 concentrations with a fixed CH 4 partial pressure in absence of N 2 showed that PHB accumulation by methanotroph could be tolerated high oxygen partial pressure and its respond to the variation of the oxygen concentration depends on the methane partial pressure. In presence of N 2 , with headspace gas replenished only when oxygen was almost depleted, the degradation of intracellular PHB has appeared. In the regimen of updating headspace gas at the point when the PHB content began to decrease, the highest PHB content (i.e., 55.5% of the dry cell weight with 901.8 mg.L -1 PHB concentration and 12.5 mg.L -1 .h -1 PHB productivity) was obtained at 0.2 atm O 2 and PHB accumulation was depressed with an oxygen concentration greater than 0.3 atm. Conclusions The methanotroph responses differentially to the increase in the oxygen partial pressure with regard to PHB accumulation either in the presence or in the absence of N2.

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Are Heart Muscle Irisin Levels and FNDC5 Gene Expression Regulated by Endurance and Resistance Exercises?

Cited by 5 publications

References 41 publications

Irisin at the crossroads of inter-organ communications: Challenge and implications

Irisin at the crossroads of inter-organ communications: Challenge and implications

Expression, Purification, and Antiserum Production of the Truncated UL31 Protein of Herpes Simplex Virus 1

Poly-β-hydroxybutyrate Production by Methylosinus trichosporium OB3b at Different Gas-phase Conditions

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