Are High Frequency Oscillations in Scalp EEG Related to Age?

Windhager, Philipp Franz; Marcu, Adrian V.; Trinka, Eugen; Bathke, Arne C.; Höller, Yvonne

doi:10.3389/fneur.2021.722657

Cited by 3 publications

(2 citation statements)

References 64 publications

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“… 41 Age-related changes seem to influence HFOs, which needs a next step to assess across childhood and adolescence. 42 …”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Complete Resection of the High-Frequency Oscillation Area in Intracranial EEG

Wang,

Guo,

van 't Klooster

et al. 2024

Neurology

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Background and Objectives High-frequency oscillations (HFOs; ripples 80–250 Hz; fast ripples [FRs] 250–500 Hz) recorded with intracranial electrodes generated excitement and debate about their potential to localize epileptogenic foci. We performed a systematic review and meta-analysis on the prognostic value of complete resection of the HFOs-area (crHFOs-area) for epilepsy surgical outcome in intracranial EEG (iEEG) accessing multiple subgroups. Methods We searched PubMed, Embase, and Web of Science for original research from inception to October 27, 2022. We defined favorable surgical outcome (FSO) as Engel class I, International League Against Epilepsy class 1, or seizure-free status. The prognostic value of crHFOs-area for FSO was assessed by (1) the pooled FSO proportion after crHFOs-area; (2) FSO for crHFOs-area vs without crHFOs-area; and (3) the predictive performance. We defined high combined prognostic value as FSO proportion >80% + FSO crHFOs-area >without crHFOs-area + area under the curve (AUC) >0.75 and examined this for the clinical subgroups (study design, age, diagnostic type, HFOs-identification method, HFOs-rate thresholding, and iEEG state). Temporal lobe epilepsy (TLE) was compared with extra-TLE through dichotomous variable analysis. Individual patient analysis was performed for sex, affected hemisphere, MRI findings, surgery location, and pathology. Results Of 1,387 studies screened, 31 studies (703 patients) met our eligibility criteria. Twenty-seven studies (602 patients) analyzed FRs and 20 studies (424 patients) ripples. Pooled FSO proportion after crHFOs-area was 81% (95% CI 76%–86%) for FRs and 82% (73%–89%) for ripples. Patients with crHFOs-area achieved more often FSO than those without crHFOs-area (FRs odds ratio [OR] 6.38, 4.03–10.09, p < 0.001; ripples 4.04, 2.32–7.04, p < 0.001). The pooled AUCs were 0.81 (0.77–0.84) for FRs and 0.76 (0.72–0.79) for ripples. Combined prognostic value was high in 10 subgroups: retrospective, children, long-term iEEG, threshold (FRs and ripples) and automated detection and interictal (FRs). FSO after complete resection of FRs-area (crFRs-area) was achieved less often in people with TLE than extra-TLE (OR 0.37, 0.15–0.89, p = 0.006). Individual patient analyses showed that crFRs-area was seen more in patients with FSO with than without MRI lesions ( p = 0.02 after multiple correction). Discussion Complete resection of the brain area with HFOs is associated with good postsurgical outcome. Its prognostic value holds, especially for FRs, for various subgroups. The use of HFOs for extra-TLE patients requires further evidence.

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“… 41 Age-related changes seem to influence HFOs, which needs a next step to assess across childhood and adolescence. 42 …”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Complete Resection of the High-Frequency Oscillation Area in Intracranial EEG

Wang,

Guo,

van 't Klooster

et al. 2024

Neurology

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“…Somatosensory evoked HFOs were enhanced in both healthy children and aged subjects 45,46 . However, the relationship between age and scalp HFOs in epileptic patients is still controversial 43,47 . Future studies could include more patients with various types of epilepsy to explore the changes in physiological and pathological scalp HFOs with age.…”

Section: Discussionmentioning

confidence: 99%

Correlation between scalp high‐frequency oscillations and prognosis in patients with benign epilepsy of childhood with centrotemporal spikes

Ji,

Zhang,

et al. 2023

CNS Neurosci Ther

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AimsThe study aimed to explore whether high‐frequency oscillations (HFOs) can predict seizure risk and atypical manifestations of benign epilepsy of childhood with centrotemporal spikes (BECTS).MethodsWe recruited 60 patients and divided them into three groups: (1) seizure‐free BECTS, (2) active typical BECTS, and (3) active atypical forms of BECTS. Electroencephalogram was used to record the number, location, average amplitude, and duration of spikes, and spike ripples were analyzed using time‐frequency technology. Multivariable logistic regression analysis was used to investigate independent predictive factors for prognosis.ResultsThe number of sleep spike ripples, rather than spikes, was an independent risk factor for the active period of the disease (odds ratio [OR] = 4.714, p = 0.003) and atypical forms of BECTS (OR = 1.455, p = 0.049); the optimal thresholds for the spike ripple rate were >0 (area under the curve [AUC] = 0.885, sensitivity = 96.15%, specificity = 73.33%) and >0.6/min (AUC = 0.936, sensitivity = 84.21%, specificity = 96.15%), respectively. Furthermore, in typical BECTS, the spike ripple rate showed significant negative correlations with time since the last seizure (ρ = −0.409, p = 0.009) and age (ρ = −0.379, p = 0.016), while the spike rate did not.ConclusionSpike ripple was a marker for distinguishing typical and atypical forms of BECTS and reflected the risk of seizure recurrence better than the spike alone. The present findings might assist clinicians in BECTS treatment.

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Physiological ripples during sleep in scalp electroencephalogram of healthy infants

Remakanthakurup Sindhu,

Phan,

Anis

et al. 2023

Sleep

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Are High Frequency Oscillations in Scalp EEG Related to Age?

Cited by 3 publications

References 64 publications

Prognostic Value of Complete Resection of the High-Frequency Oscillation Area in Intracranial EEG

Prognostic Value of Complete Resection of the High-Frequency Oscillation Area in Intracranial EEG

Correlation between scalp high‐frequency oscillations and prognosis in patients with benign epilepsy of childhood with centrotemporal spikes

Physiological ripples during sleep in scalp electroencephalogram of healthy infants

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